Recruiting

Autologous and Allogeneic Whole Cell Cancer Vaccine for Metastatic Tumors

NCT00722228 · Hadassah Medical Organization

Recruiting

In plain English

Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.

About this study

This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with melanoma and colorectal, gastric, ovarian, breast, lung and kidney epithelial cancer. Tumor cells grown in the laboratory will be modified to make them stimulatory to the immune system, irradiated to kill them, and injected to the patient eight times at two-week intervals. This protocol is expected to prolong survival of metastatic cancer patients.

Eligibility criteria

Inclusion Criteria: * One of the following metastatic cancers: Melanoma, breast, ovary, colorectal, gastric, lung or kidney * Above 18 years of age * Failure of at least one chemotherapy protocol * Clinical performance status of ECOG 0,1 * Absolute neutrophil count greater than 1000/mm3 * Serum ALT/AST less than three times the upper limit of normal * Serum creatinine less than or equal to 1.6 mg/dl. * Must be able to understand and sign the Informed Consent document Exclusion Criteria: * Below 18 years of age * Women who are pregnant * Life expectancy of less than three months

Study design

Enrollment target: 50 participants

Allocation: na

Masking: none

Age groups: adult, older_adult

Timeline

Starts: 2008-07

Estimated completion: 2027-01

Last updated: 2025-10-02

Interventions

Biological: Autologous or Allogeneic tumor cells

Sponsor

Hadassah Medical Organization · other

Contacts & investigators

ContactHani Steinberg, R.N. B.A. · contact · hanis@hadassah.org.il · : 00 972 50 7874292

ContactTamar Peretz, MD · contact · tamary@hadassah.org.il · 00 972 2 6777825

All locations (1)

Hadassah Medical OrganizationRecruiting

Jerusalem, Israel

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