RecruitingRecruiting
Genes and Environment in Multiple Sclerosis
NCT01353547 · Columbia University
In plain English
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Official title
Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility
About this study
MS is an autoimmune disease in which the immune system (white bloods cells that normally fight infection) becomes misdirected and attacks healthy tissue. In patients with MS, the misdirected white blood cells attack myelin, a lining that insulates the nerves found in the brain and spinal cord. This results in inflammation and damage in the myelin. Loss of this protective lining disrupts nerve impulses and causes abnormal function in the nervous system.
This large research study will ultimately enroll 5000 subjects who are at risk of developing MS.
Eligibility criteria
Inclusion Criteria:
* First Degree Relatives of Patients with MS, or
* Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or
* Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS
* Live in the United States
Exclusion Criteria:
* Does not match any of the inclusion criteria
Study design
Enrollment target: 5000 participants
Age groups: adult, older_adult
Timeline
Starts: 2017-10-01
Estimated completion: 2040-10
Last updated: 2026-05-14
Primary outcomes
- • Total number of subjects who are diagnosed with MS (20 years)
Sponsor
Columbia University · other
With: University of Pittsburgh, Brigham and Women's Hospital
Contacts & investigators
ContactJuliana Oyegunle · contact · jbo2120@cumc.columbia.edu · 212-305-2434
InvestigatorZongqi Xia, MD, PhD · study_director, University of Pittsburgh
All locations (5)
National Institute of Neurological Disorders and StrokeRecruiting
Bethesda, Maryland, United States
Massachusetts General HospitalTerminated
Boston, Massachusetts, United States
Brigham and Women's HospitalTerminated
Boston, Massachusetts, United States
Columbia University Irving CenterRecruiting
New York, New York, United States
University of PittsburghRecruiting
Pittsburgh, Pennsylvania, United States