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Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District, Seoul, Korea.

NCT01731665 · Asan Medical Center
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About this study
Inflammatory bowel disease (IBD), which is comprised of Crohn's disease (CD) and ulcerative colitis (UC) is a chronic inflammatory disease of gut with uncertain etiopathogenesis. According to our previous study (Yang, et al. Inflamm Bowel Dis 2008; 14: 542-549), the incidence and prevalence of IBD in Korea are still low compared with those in Western countries, but are rapidly increasing. However, the long-term trends of epidemiology of CD and UC together with their characteristics and prognosis in Korea are uncertain yet. The investigators therefore aim to elucidate the incidence and prevalence of CD and UC over a 30-year period, from 1986 to 2017, in the Songpa-Kangdong district of Seoul, Korea. In addition, the investigators also aim to reveal the clinical features at the time of diagnosis of IBD, long-term evolution of disease and prognosis.
Eligibility criteria
Inclusion Criteria: * Definite cases of CD and UC Patients are diagnosed with CD if they meet at least 2 of the following criteria: 1. clinical history of abdominal pain, weight loss, malaise, diarrhea, and/or rectal bleeding 2. endoscopic findings of mucosal cobblestoning, linear ulceration, skip areas, or perianal disease 3. radiologic findings of stricture, fistula, mucosal cobblestoning, or ulceration 4. macroscopic appearance of bowel wall induration, mesenteric lymphadenopathy, and "creeping fat" at laparotomy 5. pathologic findings of transmural inflammation and/or epithelioid granulomas Only patients who meet these criteria for at least 2 months are included. Patients are diagnosed with UC only if all 3 of the following criteria are present 1. a typical history of diarrhea or blood and pus or both in the stool for longer than 4 weeks 2. a typical sigmoidoscopic or colonoscopic picture with diffusely granular, friable, or ulcerated mucosa without rectal sparing or skip lesions or radiological signs of characteristic continuous granular or ulcerated mucosa 3. characteristic histopathological signs of inflammation on biopsy Exclusion Criteria: * IBD unclassified * Ethnic groups other than Korean
Study design
Enrollment target: 2000 participants
Age groups: child, adult, older_adult
Timeline
Starts: 2012-12
Estimated completion: 2029-06
Last updated: 2021-01-13
Primary outcomes
  • Incidence rate and prevalence rate of IBD (1986-2017 (up to 31 years))
Sponsor
Asan Medical Center · other
With: Kyung Hee University Hospital at Gangdong, Seoul National University Hospital, Seoul National University Bundang Hospital, Samsung Medical Center, Konkuk University Medical Center, National Police Hospital, Seoul Veterans Hospital, hansol hospital, Kangdong Seoul Clinic, Jamsil Seoul Surgical Clinic, Song Do Colorectal Hospital, Yang Hospital, Daehang Hospital, Kangdong Sacred Heart Hospital
Contacts & investigators
ContactSuk-Kyun Yang, M.D. · contact · sky@amc.seoul.kr · +82-2-3010-3901
ContactByong Duk Ye, M.D. · contact · bdye@amc.seoul.kr · +82-2-3010-3181
InvestigatorSuk-Kyun Yang, M.D. · principal_investigator, Asan Medical Center
All locations (1)
Asan Medical CenterRecruiting
Seoul, South Korea
Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District, Seoul, Korea. · TrialPath