Long Term Follow up of Recipients of Functional Islet Allografts

Inclusion Criteria: 1. Participation in any of the following parent studies: 2000/0329; 2000/0196; 2004/0205; 2000/0024; 2006/0200; 2006/0508; 2006/0210 2. A functioning pancreatic islet graft (absence of graft failure as defined in parent study) requiring immunosuppression. 3. Willingness of participants to continue to use an approved method of contraception during and 4 months after study participation. 4. Ability to provide written informed consent. Exclusion Criteria: 1. For female subjects: Positive pregnancy test, presently breast-feeding, or unwillingness to use effective contraceptive measures for the duration of the study and 4 months after discontinuation. For male subjects: intent to procreate during the duration of the study or within 4 months after discontinuation or unwillingness to use effective measures of contraception. Oral contraceptives, Norplant®, Depo-Provera®, and barrier devices with spermicide are acceptable contraceptive methods; condoms used alone are not acceptable. 2. Any medical condition that, in the opinion of the investigator, will interfere with safe participation in the trial.