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Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease
NCT03297775 · University of Colorado, Denver
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
The overall goal of this study is to define the phenotype of Interstitial Lung Disease (ILD), and identify factors that predict radiologic progression in those with subclinical RA-ILD, in patients with rheumatoid arthritis (RA). The investigators hypothesize that there are common core elements (e.g. clinical features, genetic variants, and/or biologic markers) between other forms of ILD (e.g. idiopathic pulmonary fibrosis, IPF) and subclinical RA-ILD that places individuals at risk for the development of lung disease.
Eligibility criteria
Inclusion Criteria:
1. ≥ 45years old
2. Diagnosis of RA using the 2010 American College of Rheumatology (ACR) criteria
Exclusion Criteria:
1. Inability to give informed consent
2. Pregnant women
3. History of interstitial lung disease
4. Evidence of other causes of diffuse parenchymal lung disease such as infection, drug toxicity, other autoimmune processes, etc.
5. Subjects over the age of 90 years old or less than 45 years old
Study design
Enrollment target: 750 participants
Age groups: adult, older_adult
Timeline
Starts: 2017-06-22
Estimated completion: 2027-06
Last updated: 2023-11-30
Primary outcomes
- • Presence of interstitial lung disease on high resolution CT (HRCT) chest imaging (3-5 years)
Sponsor
University of Colorado, Denver · other
Contacts & investigators
ContactHaylie A Lengel · contact · haylie.lengel@cuanschutz.edu · 970-376-8303
ContactJoyce S Lee, MD · contact · joyce.lee@ucdenver.edu · 303-724-6109
InvestigatorJoyce S Lee, MD · principal_investigator, University of Colorado, Denver
All locations (1)
University of Colorado - Anschutz Medical CampusRecruiting
Aurora, Colorado, United States