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Prospective Longitudinal Observational Research in Atopic Dermatitis
NCT04240522 · University of Zurich
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Prospective Longitudinal Observational Research Study to Investigate the Remission of Atopic Dermatitis and Associated Allergic Diseases
About this study
Primary Objetive:
In the planned project, the main objective is to identify endogenous (e.g. immunological and molecular factors) and exogenous factors (e.g. environmental, socioeconomic and microbial factors) that influence the course and remission of AD. More specifically to identify factors that are significantly different between patients that have or do not have remission from AD.
Secondary Objective:
(i) To identify endogenous and exogenous factors such as immunological, molecular and microbial factors to separate subgroups of patients (endotypes) with distinct local and systemic inflammatory responses.
(ii) To identify potential biomarkers predicting the individual clinical course of AD and other atopic diseases including asthma, food allergy and allergic rhinitis.
Eligibility criteria
Inclusion Criteria:
* Age 0 - 85 years
* Diagnosis of AD and/or another disease of the atopic group (i.e. allergic rhinitis, allergic asthma, food allergy)
* The inclusion of patients in this study is independent from the current therapy. During the study all patients will be kept on a therapy that is medically indicated
The inclusion criteria for healthy controls in this study are as follows:
* Age 0 - 85 years
* No diagnosis or history of allergic disease
* The inclusion of patients in this study is independent from the current therapy. During the study all patients will be kept on a therapy that is medically indicated
Written consent will be obtained after detailed information of the study was given to the participant.
Exclusion Criteria
\- Unable to give consent or refusal to participate in the study
Study design
Enrollment target: 1000 participants
Age groups: child, adult, older_adult
Timeline
Starts: 2017-04-04
Estimated completion: 2031-03-30
Last updated: 2026-02-05
Primary outcomes
- • Remission of atopic dermatitis and associated allergic diseases (5 years)
Sponsor
University of Zurich · other
With: University of Bonn
All locations (1)
Allergy Unit, Dept. of Dermatology, Unviersity Hosptial of ZurichRecruiting
Zurich, Canton of Zurich, Switzerland