RecruitingRecruiting
Pathogenic Study of Adult Immune Enteropathies
NCT04280510 · Institut National de la Santé Et de la Recherche Médicale, France
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
Eligibility criteria
Inclusion Criteria:
* 18 years or over
* affiliated to social insurance
* signed informed consent
Exclusion Criteria:
* pregnancy
* under guardianship
* not able to sign informed consent
Study design
Enrollment target: 200 participants
Age groups: adult, older_adult
Timeline
Starts: 2020-02-27
Estimated completion: 2033-02-27
Last updated: 2025-09-18
Interventions
Genetic: Blood sample collection; gastrointestinal biopsy
Primary outcomes
- • Intestinal Lymphocytes count (Baseline)
- • DNA sequencing (Baseline)
Sponsor
Institut National de la Santé Et de la Recherche Médicale, France · other_gov
With: Imagine Institute
Contacts & investigators
ContactGeorgia MALAMUT, MD, PhD · contact · georgia.malamut@aphp.fr · 33 1 58 41 41 76
ContactAnaïs LEVESCOT, MD, PhD · contact · anais.levescot@inserm.fr · 33 1 42 75 42 77
InvestigatorGeorgia MALAMUT, MD, PhD · principal_investigator, APHP, Université de Paris (Université Paris Descartes)
All locations (4)
Hôpital Henri MondorNot Yet Recruiting
Créteil, France
Hôpital BicêtreNot Yet Recruiting
Le Kremlin-Bicêtre, France
Hôpital Saint LouisNot Yet Recruiting
Paris, France
Hôpital CochinRecruiting
Paris, France