RecruitingRecruiting
Cortical-Basal Ganglia Speech Networks
NCT04286308 · Massachusetts General Hospital
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
Speech production is disrupted in a number of neurological diseases that involve the basal ganglia, including Parkinson's disease (PD) and dystonia. The investigators will use a novel experimental approach and combination of analytic techniques to elucidate the contribution of neural activity in cortical-basal ganglia circuits to the hierarchical control of speech production, in subjects undergoing deep brain stimulation surgery.
Eligibility criteria
Inclusion Criteria:
1. Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia.
2. Subjects able to provide informed consent and comply with task instructions.
3. Subjects 18-85 years old
Exclusion Criteria:
1. Subjects with reported hearing loss.
2. Non-English-speaking subjects
Study design
Enrollment target: 80 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2020-10-01
Estimated completion: 2027-02
Last updated: 2026-03-25
Interventions
Other: electrophysiological data collection
Primary outcomes
- • The number of subjects providing the interpretable speech related electrophysiological data collection. (Duration of single DBS surgery)
Sponsor
Massachusetts General Hospital · other
Contacts & investigators
ContactMark Richardson, MD, PhD · contact · mark.richardson@mgh.harvard.edu · 617-726-8849
ContactErin Donahue, PhD · contact · ekdonahue@mgh.harvard.edu
All locations (1)
Massachusetts General HospitalRecruiting
Boston, Massachusetts, United States