RecruitingRecruiting
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
NCT04838678 · University of Texas Southwestern Medical Center
In plain English
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Official title
Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension
About this study
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
Eligibility criteria
Inclusion Criteria:
* Control - BMI\<30, age 18-55
* Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring
Exclusion Criteria:
All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,
Study design
Enrollment target: 100 participants
Allocation: non_randomized
Masking: none
Age groups: adult
Timeline
Starts: 2021-07-18
Estimated completion: 2026-08-31
Last updated: 2025-08-24
Interventions
Drug: Neuropeptide Y
Primary outcomes
- • Blood flow measured by doppler ultrasound (Acutely on the day of study)
- • Muscle sympathetic nervous system activity (Acutely on the day of study)
Sponsor
University of Texas Southwestern Medical Center · other
Contacts & investigators
ContactChristopher M Hearon, Ph.D. · contact · christopher.hearon@utsouthwestern.edu · 214-345-4624
ContactMary Childers · contact · marychilders@texashealth.org · 214-345-6459
All locations (1)
University of Texas Southwestern Medical CenterRecruiting
Dallas, Texas, United States