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Video Education With Result Dependent dIsclosure
NCT05225428 · Dana-Farber Cancer Institute
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
This study consists of two parts:
* Qualitative assessment:
* This part of the research study involves watching a brief educational video about genetic testing for inherited cancer risk (about 8 minutes) before completing a short interview by video or telephone with trained researchers. This interview will be digitally recorded for later review. Participation in the study will be considered complete after the interview is finished. The qualitative assessment study will recruit 20 total participants.
* The data gathered from this study will inform the refinement and adaptation of the VERDI model for the subsequent randomized controlled trial.
* Randomized control trial:
* A randomized controlled trial (RCT) will evaluate the VERDI model vs. standard genetic counseling in 1000 participants
Eligibility criteria
Inclusion Criteria:
* Age ≥ 18 years
* Current or prior diagnosis of breast cancer, ovarian cancer, pancreatic cancer, prostate cancer, colorectal cancer, renal cancer, melanoma, or sarcoma
* Ability to understand spoken or written English or Spanish in a healthcare context
* Ability to understand and the willingness to sign a written informed consent document
* Black or Latinx (qualitative assessment study only)
Exclusion Criteria:
* Prior cancer genetic testing
* Prior germline genetic testing
* Active hematologic malignancy (e.g. chronic lymphocytic leukemia)
* Currently pregnant
* Currently incarcerated
Study design
Enrollment target: 1020 participants
Allocation: randomized
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2022-08-04
Estimated completion: 2026-09-01
Last updated: 2026-02-25
Interventions
Behavioral: Video EducationBehavioral: Genetic Counseling
Primary outcomes
- • Video Education Acceptability (Qualitative Interview Study) (3 Weeks)
Sponsor
Dana-Farber Cancer Institute · other
With: National Cancer Institute (NCI), National Human Genome Research Institute (NHGRI)
Contacts & investigators
ContactHuma Q. Rana, MD. MPH · contact · humaQ_rana@dfci.harvard.edu · 617) 632-6292
InvestigatorHuma Q. Rana, MD., MPH · principal_investigator, Dana-Farber Cancer Institute
All locations (1)
Dana Farber Cancer InstituteRecruiting
Boston, Massachusetts, United States