RecruitingRecruiting
Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays
NCT05234177 · Tempus AI
In plain English
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Official title
Tempus CRC Surveillance Study: A Longitudinal Circulating Tumor DNA (ctDNA) Biomarker Profiling Study of Patients With Colorectal Cancer (CRC) Using Comprehensive Next-Generation Sequencing (NGS)Assays
About this study
The study is an observational multicenter evaluation of participants with colorectal cancer (CRC) who will receive longitudinal plasma ctDNA biomarker profiling in addition to their standard-of-care therapy and disease surveillance.
Eligibility criteria
Inclusion Criteria:
* Known or suspected colorectal adenocarcinoma (Stage I to IVA disease)
* Planning to undergo or has undergone a surgical resection for suspected adenocarcinoma of the colon or rectum with curative intent.
* 18 years old or older
* Willing and able to provide informed consent
* Willing to have additional blood samples collected during routine surveillance visits
Exclusion Criteria:
* Not willing to have additional blood samples collected
* Pathology that is not consistent with colorectal adenocarcinoma
Study design
Enrollment target: 300 participants
Age groups: adult, older_adult
Timeline
Starts: 2022-06-21
Estimated completion: 2029-02
Last updated: 2025-05-06
Interventions
Other: Observation
Primary outcomes
- • Recurrence-Free Survival (2 years)
Sponsor
Tempus AI · industry
Contacts & investigators
ContactCRC Surveillance Study · contact · gemini-crc@tempus.com · (833) 514-4187
InvestigatorKristiyana Kaneva, MD, MS · principal_investigator, Tempus AI, Inc.
All locations (20)
Mercy Clinic Oncology - Fort SmithRecruiting
Fort Smith, Arkansas, United States
MemorialCareRecruiting
Fountain Valley, California, United States
The Center for Cancer and Blood DisordersRecruiting
Bethesda, Maryland, United States
Mercy Clinic Oncology and Hematology - JoplinRecruiting
Joplin, Missouri, United States
Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer CenterRecruiting
Springfield, Missouri, United States
Washington University School of MedicineRecruiting
St Louis, Missouri, United States
Mercy Clinic Oncology and Hematology - Sindelar Cancer CenterRecruiting
St Louis, Missouri, United States
Mercy Clinic Oncology and Hematology - David C. Pratt Cancer CenterRecruiting
St Louis, Missouri, United States
Nebraska Cancer SpecialistsRecruiting
Omaha, Nebraska, United States
Southeastern Medical Oncology CenterRecruiting
Goldsboro, North Carolina, United States
Aultman HospitalRecruiting
Canton, Ohio, United States
TriHealth Cancer InstituteRecruiting
Cincinnati, Ohio, United States
Ohio State UniversityRecruiting
Columbus, Ohio, United States
OhioHealth Research InstituteRecruiting
Columbus, Ohio, United States
Toledo Clinic Cancer CenterRecruiting
Toledo, Ohio, United States
Mercy Clinic Oncology and Hematology - ColettaRecruiting
Oklahoma City, Oklahoma, United States
Cancer Care Associates of YorkRecruiting
York, Pennsylvania, United States
Utah Cancer SpecialistsRecruiting
Salt Lake City, Utah, United States
University of Washington / Fred Hutchinson Cancer CenterRecruiting
Seattle, Washington, United States
ThedaCare Regional Cancer CenterRecruiting
Appleton, Wisconsin, United States