← Back to searchRecruitingRecruiting
ERP to Improve Functioning in Veterans With OCD
NCT05240924 · VA Office of Research and Development
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Exposure and Response Prevention to Improve Functioning in Veterans With Obsessive Compulsive Disorder
About this study
The proposed 4-year multisite RCT will compare outcomes of VTH-delivered ERP to those of a stress management training control condition among 160 Veterans with OCD. Half of the sample with have comorbid PTSD. The primary aim will examine whether participants' functioning, quality of life, and OCD symptoms differ as a function of the intervention (ERP vs. control). The secondary aim will examine these outcomes among the half of the sample with comorbid OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.
Eligible Veteran participants will be randomized to ERP or to the control condition. Veterans randomized to ERP will receive 16 weekly ERP sessions delivered via VTH. Control participants will receive 16 weekly sessions of a stress management training intervention delivered via VTH. Participants in both conditions will complete assessments at post-treatment and 6 months after completing treatment. Participants in the ERP condition will also complete an assessment of treatment satisfaction and a qualitative exit interview assessing the Veterans' perceptions of the impact of treatment on multiple domains of functioning, including the impact on PTSD symptoms. Providers and VA administrators will participate in qualitative interviews regarding the implementation potential of ERP in VA.
Eligibility criteria
Inclusion Criteria:
* Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska: the VISN 2 Clinical Resource Hub which provides telehealth services to New Jersey, New York, and northern Pennsylvania, and the VISN 6 Clinical Resource Hub which provides telehealth services to North Carolina and Virginia.
* Willingness to participate in Exposure and Response Prevention(ERP)
Exclusion Criteria:
* Significant cognitive impairment or conditions that threaten safety (current psychosis, mania, imminent suicidality including plan or intent, and treatment-interfering moderate to severe substance use).
* Potential participants taking psychotropic medications must be on a stable dose of these medications for at least 6 weeks prior to study enrollment.
Study design
Enrollment target: 160 participants
Allocation: randomized
Masking: single
Age groups: adult, older_adult
Timeline
Starts: 2022-10-03
Estimated completion: 2026-05-31
Last updated: 2025-11-13
Interventions
Behavioral: Exposure and Response PreventionOther: Stress Management Training
Primary outcomes
- • Work and Social Adjustment Scale (WSAS) - Change (Baseline, Post Treatment (4-6 Months after Randomization), 6 Months Post Treatment)
Sponsor
VA Office of Research and Development · fed
Contacts & investigators
ContactMatthew G Escamilla, BS · contact · matthew.escamilla@va.gov · (713) 440-4461
ContactTerri L Fletcher, PhD · contact · Terri.Fletcher@va.gov · (713) 440-4400
InvestigatorTerri L. Fletcher, PhD · principal_investigator, Michael E. DeBakey VA Medical Center, Houston, TX
All locations (18)
East Orange Campus of the VA New Jersey Health Care System, East Orange, NJRecruiting
East Orange, New Jersey, United States
VA Western New York Healthcare System, Buffalo, NYRecruiting
Buffalo, New York, United States
VA NY Harbor Healthcare System, New York, NYRecruiting
New York, New York, United States
Northport VA Medical Center, Northport, NYRecruiting
Northport, New York, United States
James J. Peters VA Medical Center, Bronx, NYRecruiting
The Bronx, New York, United States
Asheville VA Medical Center, Asheville, NCRecruiting
Asheville, North Carolina, United States
Durham VA Medical Center, Durham, NCRecruiting
Durham, North Carolina, United States
Fayetteville VA Medical Center, Fayetteville, NCRecruiting
Fayetteville, North Carolina, United States
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NCRecruiting
Salisbury, North Carolina, United States
VA Roseburg Healthcare System, Roseburg, ORRecruiting
Roseburg, Oregon, United States
VA Southern Oregon Rehabilitation Center and Clinics, White City, ORRecruiting
White City, Oregon, United States
Ralph H. Johnson VA Medical Center, Charleston, SCRecruiting
Charleston, South Carolina, United States
Michael E. DeBakey VA Medical Center, Houston, TXRecruiting
Houston, Texas, United States
Hampton VA Medical Center, Hampton, VARecruiting
Hampton, Virginia, United States
Hunter Holmes McGuire VA Medical Center, Richmond, VARecruiting
Richmond, Virginia, United States
Salem VA Medical Center, Salem, VARecruiting
Salem, Virginia, United States
Spokane VA Medical Center, Spokane, WARecruiting
Spokane, Washington, United States
Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WARecruiting
Walla Walla, Washington, United States