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Evaluation of the Impact of Taking American Ginseng for 8 Weeks on Fatigue in Patients Treated for Localized Breast or Gynecological Cancer

NCT05241405 · Centre Francois Baclesse
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Official title
Evaluation of the Impact of Taking American Ginseng for 8 Weeks on Fatigue in Patients Treated for Localized Breast or Gynecological Cancer - Randomized, Placebo-controlled, Double-blind Study
About this study
This is a multicenter randomized trial in breast cancer patients reporting cancer-related fatigue to evaluate the efficacy and safety of Qiseng® based on extract of American ginseng combined with vitamin C from extract of Camu Camu berries
Eligibility criteria
Inclusion Criteria: * Patients with localized breast or gynecological cancer treated as curative adjuvant and/or neoadjuvant chemotherapy and/or adjuvant radiotherapy. These treatments must have been completed within 6 months of inclusion. * Patient reporting a chronic, stable fatigue state at investigator assessment, defined as a fatigue score ≥ 4 on the visual analog scale rated up to 10, experienced for at least one month * Maintenance therapy with hormone therapy or other maintenance therapy (trastuzumab, bevacizumab…) is allowed before and/or during the study (except for pembrolizumab, abemaciclib and PARP inhibitors, which are not authorized) * Patient 18 years of age or older * Effective contraception in women of childbearing age * Patient affiliated to a social security plan * Signed informed consent Exclusion Criteria: * Other identified causes of fatigue (anemia of grade \> 2, underlying chronic disease known to be associated with fatigue) * Ongoing chemotherapy (patients scheduled for oral capecitabine or trastuzumab-emtasin in the adjuvant setting are not eligible) * Metastatic breast or gynecological cancer * Ongoing treatment with a tyrosine kinase inhibitor or other P-gp transported molecule or Pembrolizumab or PARP inhibitors * Patient requiring oral diabetes therapy * Regular intake of Vitamin C (in addition to what is provided by the diet) * Patients with chronic pain requiring daily treatment with analgesics, anti-inflammatory drugs or corticosteroids * Consumption of ginseng-based products in the month prior to inclusion * Hypersensitivity to any of the components of Qiseng or placebo * Pregnant or breastfeeding patient * Simultaneous participation in another therapeutic clinical trial (trial using an experimental product) * Patient deprived of liberty, under guardianship or curatorship * Patient unable to undergo the medical follow-up of the trial for geographical, social or psychopathological reasons * History of any other malignant disease during the last 3 years, except for skin cancer other than melanoma, carcinoma in situ of the uterus. Any other solid tumor or lymphoma (without bone marrow involvement) must have been treated and show no signs of recurrence for at least 3 years
Study design
Enrollment target: 354 participants
Allocation: randomized
Masking: double
Age groups: adult, older_adult
Timeline
Starts: 2022-09-27
Estimated completion: 2027-09
Last updated: 2024-10-01
Interventions
Dietary Supplement: QISENGDietary Supplement: PLACEBO
Primary outcomes
  • Fatigue score change [min :5; max:20] (After 1 week and 4 weeks after the end of treatment (so 8 weeks of treatment))
Sponsor
Centre Francois Baclesse · other
With: NATSUCA laboratory, Groupement Interrégional de Recherche Clinique et d'Innovation
Contacts & investigators
ContactCarine SEGURA, MD · contact · c.segura@baclesse.unicancer.fr · +33231455050
ContactAlexandra LECONTE · contact · a.leconte@baclesse.unicancer.fr
All locations (10)
ARCOCEA_Clinique EuropeNot Yet Recruiting
Amiens, France
Ch BayeuxNot Yet Recruiting
Bayeux, France
Centre Pierre CurieNot Yet Recruiting
Beuvry, France
Centre François BaclesseRecruiting
Caen, France
Polyclinique du ParcNot Yet Recruiting
Caen, France
Ch CalaisRecruiting
Calais, France
Ch CherbourgNot Yet Recruiting
Cherbourg, France
Clinique de FlandreRecruiting
Coudekerque-Branche, France
Centre Henri BecquerelRecruiting
Rouen, France
Clinique des DentellièresRecruiting
Valenciennes, France
Evaluation of the Impact of Taking American Ginseng for 8 Weeks on Fatigue in Patients Treated for Localized Breast or Gynecological Cancer · TrialPath