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Research on Optimal Diagnosis and Treatment of Cardiorenal Syndrome
NCT05397392 · Nanjing First Hospital, Nanjing Medical University
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
Cardiorenal syndrome is a clinical syndrome caused by acute or chronic injury of one of the heart and kidney resulting to acute or chronic dysfunction of the other organ. In recent years, the morbidity of cardiorenal syndrome has increased rapidly in China. Its condition is complex and difficult to treat. Due to the lack of studies specifically targeting the cardiorenal syndrome population, there is no systematic in-depth understanding of the pathogenesis and risk factors of this kind of disease. In clinic, the course of various types of cardiorenal syndrome is complex and difficult to be summarized into a specific type. Therefore, we intend to conduct a clinical systematic observation and research on such patients so as to optimize a more reasonable treatment scheme.
Eligibility criteria
Inclusion Criteria:
Patients meet the diagnosis of various types of cardiorenal syndrome according to the classification standards of various types formulated by KDIGO and ADQI expert consensus. Different syndromes were identified and classified into five subtypes. Acute CRS (type 1): acute worsening of heart function (AHF-ACS) leading to kidney injury and/or dysfunction. Chronic cardio-renal syndrome (type 2): chronic abnormalities in heart function (CHF-CHD) leading to kidney injury and/or dysfunction. Acute reno-cardiac syndrome (type 3): acute worsening of kidney function (AKI) leading to heart injury and/or dysfunction. Chronic reno-cardiac syndrome (type 4): chronic kidney disease leading to heart injury, disease, and/or dysfunction. Secondary CRS (type 5): systemic conditions leading to simultaneous injury and/or dysfunction of heart and kidney.
Exclusion Criteria:
Pregnant or breastfeeding women; Female patients with recent birth plans; Patients who cannot follow up on medications.
Study design
Enrollment target: 1200 participants
Age groups: adult, older_adult
Timeline
Starts: 2016-01
Estimated completion: 2027-12
Last updated: 2022-06-02
Interventions
Other: guideline recommended routine treatment
Primary outcomes
- • Hospitalization due to worsening of renal or cardiac function (1 year)
- • All-cause deaths (1 year)
Sponsor
Nanjing First Hospital, Nanjing Medical University · other
Contacts & investigators
ContactYue Zhou, master of medicine · contact · 56005460@qq.com · +8615380998793
ContactXiao-xia Chen, master of medicine · contact · zygyx2022@163.com · +8615380998950
All locations (1)
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Nanjing, China