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Clinical Indicators and Brain Image Data: a Study Based on Kailuan Cohort
NCT05453877 · Beijing Friendship Hospital
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Clinical Indicators and Brain Image Data: a Cohort Study Based on Kailuan Cohort
About this study
The investigators will analyze the relationship between the medical history, physiological indicators and the cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs in a large sample size of subjects (participants), to identify the influencing factors of the occurrence and development of cerebral small vessel disease as well as the structural and functional changes of the brain/head and neck organs, so as to provide objective clues for early intervention of the disease and improve clinical outcomes.
Eligibility criteria
Inclusion Criteria:
1. Age from 18 to 90 years old;
2. Comes from the Kailuan Cohort, completed ≥1 visits which the medical history, physiological indicators were measured;
3. Without contraindications of CT and MR scan;
4. Can cooperate with the measurement of the medical history, physiological indicators and brain imaging.
Exclusion Criteria:
1. Known clinical history with congenital or acquired organic diseases (such as aortic stenosis);
2. Known history of drug abuse;
3. Pregnant and lactating women; 4. With clinical history of psychiatric diseases (such as schizophrenia).
Study design
Enrollment target: 1000 participants
Age groups: adult, older_adult
Timeline
Starts: 2022-08-01
Estimated completion: 2030-08-01
Last updated: 2022-10-31
Interventions
Other: No intervention will be applied.
Primary outcomes
- • White matter hyperintensity of the brain measured by MRI (magnetic resonance imaging) (every two years up to 30 years)
- • microbleeds of the brain measured by MRI (magnetic resonance imaging) (every two years up to 30 years)
- • Lacunes of the brain measured by MRI (magnetic resonance imaging) (every two years up to 30 years)
Sponsor
Beijing Friendship Hospital · other
With: KaiLuan General Hospital
Contacts & investigators
ContactZhenchang Wang · contact · cjr.wzhch@vip.163.com · +86-13501163497
ContactJing Li · contact · lijingxbhtr@163.com · +86-13693544716
All locations (2)
Beijing Friendship Hospital, Capital Medical UniversityNot Yet Recruiting
Beijing, Beijing Municipality, China
Kailuan General HospitalRecruiting
Tangshan, Hebei, China