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Specific Dietary Pattern for Crohn's Disease Patients Following Surgery
NCT05502965 · Second Affiliated Hospital, School of Medicine, Zhejiang University
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Effectiveness and Pathogenesis of Specific Dietary Pattern in Maintaining Remission Among Crohn's Disease(CD) Patients Following Surgery
About this study
The dietary therapy is based on the nutrient composition of exclusive enteral nutrition and is more in line with Chinese patients' dietary habits and economic conditions.
Eligibility criteria
Inclusion Criteria:
1. Diagnose CD according to endoscopy, histology and imaging;
2. Bowel resection for CD
3. Oral nutritional preparations or food can be given after surgery
Exclusion Criteria:
1. Plan operation within 5 weeks after surgery;
2. Presence of an ileostomy or colostomy
3. Complete bowel obstruction or fibrous stricture
4. Pregnancy or breastfeeding;
5. Plan to use biological agents within 5 weeks after surgery;
6. Plan to use corticosteroids or prednisone greater than 20 mg per day or equivalent doses of drugs to maintain remission within 5 weeks after surgery;
7. Plan to use probiotics or prebiotics for more than 1 week after surgery;
8. Antibiotics are used for more than 2 weeks after surgery;
9. Hypersensitivity to known components of enteral nutrition;
10. BMI less than 14 or greater than 28 kg/m2;
11. Celiac disease;
12. Complicated with other autoimmune diseases such as diabetes or rheumatic disease, autoimmune liver disease, psoriasis;
13. Mental illness;
14. Malignant tumors
15. Those who are not suitable for body composition analysis (such as pacemakers and metal objects in the body)
16. Participating in other clinical trials
17. The researcher believes that others are not suitable to participate in this study.
Study design
Enrollment target: 35 participants
Allocation: randomized
Masking: none
Age groups: child, adult, older_adult
Timeline
Starts: 2022-09-17
Estimated completion: 2026-06-30
Last updated: 2026-02-02
Interventions
Other: dietary patternOther: EEN
Primary outcomes
- • Quality of Life(IBDQ) (The two groups of patients were scored at first week and sixth week after surgery.)
Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University · other
Contacts & investigators
Contacthuang xiaoxu · contact · xiaoxuhuang0909@126.com · +86-0571-87783851
Contactlu yanyu · contact · luyanyu@zju.edu.cn · +86-0571-87783851
Investigatoryu qiao · principal_investigator, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Investigatorguo huilan · study_director, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
All locations (1)
2nd Affiliated Hospital, School of Medicine, Zhejiang UniversityRecruiting
Hangzhou, Zhejiang, China