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Biobank and Register of Patients With Agresive Tumors for Translational and Analytical Research
NCT05539677 · N.N. Petrov National Medical Research Center of Oncology
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Analysis of the Immunogenetic Profile of Patients With Aggressive Course of Malignant Neoplastic Process Resistant to the Standard Treatment Approaches: a Translational Study
About this study
The investigators will collect biosamples of patient blood and tumour tissue for further immunological analysis of blood cell subpopulations, immunosupressive factors concentration, HLA expression an lymphocytes and tumour tissue, and and cancer testis antigenes expression on tumour cells, as well as clinical data on patient's stage, therapy, response and demographics. Possible prognostic and predictive dynamic biomarkers will be discovered for individualisation of treatment strategies
Eligibility criteria
Inclusion Criteria:
* Signed inform consent
* Histolgically verified solid tumour
* Receiving systemic therapy for neoplasm
* Has archival tumour tissue
* Provide biosamples with living tumour tissue or blood samples for immunologic assessment
Exclusion Criteria:
* Concurrent Lymphoprolipherative disorder
* Patients after stem cell or bone marrow thansplantation
* Incomplete informaton on previous cancer history or medical history
* Patients with known primary immunodeficiency
* Patients receiving immunosupressive therapy for concurrent illness
* Pregnant patients
Study design
Enrollment target: 1000 participants
Age groups: child, adult, older_adult
Timeline
Starts: 1998-09
Estimated completion: 2030-12
Last updated: 2024-05-06
Primary outcomes
- • Progression in 3 mo (3 month)
Sponsor
N.N. Petrov National Medical Research Center of Oncology · other
Contacts & investigators
ContactAleksei Novik, MD, PhD · contact · alexey.viktorovich.novik@gmail.com · +78124399505
ContactTatiana Nekhaeva, MD, PhD · contact · nehaevat151274@mail.ru · +78124399514
InvestigatorIrina Baldueva, MD, PhD, DSc · study_director, N.N. Petrov NMRC of Oncology
All locations (1)
N.N. Petrov NMRC of Oncology, Oncoimmunology dep.Recruiting
Saint Petersburg, Russia