Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

NCT05557864 · University of Minnesota

Recruiting

In plain English

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Official title

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2

About this study

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Eligibility criteria

Inclusion Criteria: * diagnosis of idiopathic PD * have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN) * Existing 7T brain imagery Exclusion Criteria: * history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs * other significant neurological disorder * history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR) * post-operative complications or adverse effects

Study design

Enrollment target: 24 participants

Allocation: na

Masking: none

Age groups: adult, older_adult

Timeline

Starts: 2016-08-25

Estimated completion: 2026-12-31

Last updated: 2026-01-26

Interventions

Device: Deep Brain Stimulation

Primary outcomes

• Changes in the combined elastic, viscous and inertial resistance across conditions will be assessed by integrating the resistive torque (3 weeks)

Sponsor

University of Minnesota · other

Contacts & investigators

ContactColum MacKinnon, PhD · contact · cmackinn@umn.edu

All locations (1)

University Of MinnesotaRecruiting

Minneapolis, Minnesota, United States

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