RecruitingRecruiting
Micro-UltraSound In Cancer - Active Surveillance
NCT05558241 · University of Alberta
In plain English
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Official title
Micro-UltraSound In Cancer - Active Surveillance (MUSIC-AS)
About this study
This study will compare the two imaging modalities (MRI and micro-ultrasound) during Active Surveillance of prostate cancer (PCa). Progression to clinically significant PCa will be assessed by first taking micro-US targeted samples (while blinded to MRI results), followed by MRI targeted samples, finishing with 12 systematic biopsy cores. The primary goal is to compare microUS to MRI for the detection of ≥GG2 PCa at confirmatory biopsy. This study will also collect blood samples from participants to be used for future biomarker studies.
Eligibility criteria
Inclusion Criteria:
* Adult men with Gleason Grade Group 1 prostate cancer managed by active surveillance who require a confirmatory prostate biopsy
Exclusion Criteria:
* Men who cannot undergo a prostate MRI
* Men who cannot undergo a prostate biopsy
Study design
Enrollment target: 210 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2022-11-30
Estimated completion: 2033-07-30
Last updated: 2026-04-13
Interventions
Device: High-resolution micro-ultrasound
Primary outcomes
- • Cancer upgrading during Active surveillance by micro-ultrasound and MRI (Immediately after biopsy.)
Sponsor
University of Alberta · other
Contacts & investigators
ContactAdam Kinnaird, MD, PhD · contact · ask@ualberta.ca · 780-407-5800
ContactStacey Broomfield, PhD · contact · sbroomfi@ualberta.ca · 780-407-5800
InvestigatorAdam Kinnaird, MD, PhD · principal_investigator, University of Alberta
All locations (5)
University of California Los Angeles, Department of UrologyRecruiting
Los Angeles, California, United States
Kipnes Urology Centre - Kaye Edmonton ClinicRecruiting
Edmonton, Alberta, Canada
University of British ColumbiaRecruiting
Vancouver, Alberta, Canada
CIUSSS du Nord-de-L'Ile-De-MontrealRecruiting
Montreal, Quebec, Canada
HumanitasRecruiting
Milan, Italy