In plain English
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About this study
By defining the strength and direction of connectivity patterns at rest and during movement across the basal ganglia-thalamocortical (BGTC) network we will characterize the role of individual circuits in motor performance and cognitive function, paving the way for future development of optimization algorithms for DBS that take advantage of this understanding.
Eligibility criteria
Inclusion Criteria:
* Implanted with a DBS system
* Existing 7T imagery (either done as standard-of-care or done as part of Noam Harel's study, IRB #1210M22183)
* Diagnosed with idiopathic Parkinson's Disease
* Minimum age 21 years
Exclusion Criteria:
* Other significant neurological disorder, as determined by PI
* Diagnosis of dementia
* Pregnant
Study design
Enrollment target: 100 participants
Age groups: adult, older_adult
Timeline
Starts: 2024-03-05
Estimated completion: 2027-03-01
Last updated: 2026-04-08
Primary outcomes
- • Motor association with pathway activation patterns (6 months post surgery)
- • Cognitive outcome 1 association with pathway activation pattern (6 months post surgery)
- • Cognitive outcome 2 association with pathway activation pattern (6 months post surgery)
Sponsor
University of Minnesota · other
Contacts & investigators
ContactNiecy Beltz · contact · beltz070@umn.edu · 612-626-5711
InvestigatorJerrold Vitek, MD, PhD · principal_investigator, University of Minnesota
All locations (1)
University Of MinnesotaRecruiting
Minneapolis, Minnesota, United States