A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

Inclusion Criteria * Documented COPD diagnosis for ≥ 12 months * History of frequent exacerbations, defined as having had 2 or more moderate or severe COPD exacerbations within 12 months prior to screening * Post-bronchodilator FEV1 ≥ 20% and \< 80% of predicted at screening * Post-bronchodilator FEV1/FVC \< 0.70 at screening * Modified Medical Research Council (dyspnea scale) (mMRC) score ≥ 2 * Current tobacco smoker or former smoker with a history of smoking ≥ 10 pack-years * On optimized COPD maintenance therapy as defined below for ≥ 12 months prior to screening, and stable on current therapy for at least 4 weeks prior to screening: Inhaled corticosteroid (ICS) plus long-acting beta-agonist (LABA), Long-acting muscarinic antagonist (LAMA) plus LABA, ICS plus LAMA plus LABA * Chest X-ray or computed tomography (CT) scan within 6 months prior to screening or chest X-ray during the screening period that confirms the absence of clinically significant lung disease besides COPD Exclusion Criteria * Current documented diagnosis of asthma * History of clinically significant pulmonary disease other than COPD * Diagnosis of 1-antitrypsin deficiency * History of long-term treatment with oxygen at \> 4.0 liters/minute * Lung volume reduction surgery or procedure within 12 months prior to screening * Individuals participating in, or scheduled for, an intensive COPD rehabilitation program (participants who are in the maintenance phase of a rehabilitation program are eligible) * History of lung transplant * Any infection that resulted in hospital admission for ≥ 24 hours and/or treatment with oral, IV, or IM antibiotics within 4 weeks prior to or during screening * Upper or lower respiratory tract infection within 4 weeks prior to or during screening * Treatment with oral, IV, or IM corticosteroids within 4 weeks prior to initiation of study drug * Initiation of or change in non-biologic immunomodulatory or immunosuppressive therapy within 3 months prior to screening * Unstable cardiac disease, myocardial infarction, or New York Heart Association Class III or IV heart failure within 12 months prior to screening