In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Psorcast Study: A Smartphone-based Study of Psoriasis and Psoriatic Arthritis
About this study
Psoriatic disease exhibits a spectrum of symptoms and can transition from psoriasis (PsO), largely affecting the skin, to psoriatic arthritis (PsA) involving widespread musculoskeletal inflammation. Early detection of the PsO-to-PsA transition and rapid administration of effective treatment is essential, as a delay in diagnosing PsA by as little as 6 months can lead to irreversible joint damage. This "ticking clock" paradigm drives the need for frequent monitoring and effective therapeutic intervention as early as possible to attenuate or possibly prevent disease progression. Using a suite of smartphone-based measurements in an app called Psorcast (psoriasis forecasts), we aim to aggregate weekly, symptom measurements from participants in a remote, longitudinal observational study to map the trajectories of treatment response and disease progression. In this study, we will explore measurements of psoriatic disease activity at least an order of magnitude more frequently (weekly vs. quarterly) than standard clinical practice or clinical trial designs. This study is not meant to provide a medical diagnosis, treatment, or medical advice. It is meant to provide a scalable, inexpensive, non-invasive and frequent measure and tracking of psoriasis and psoriatic arthritis for research purposes.
Eligibility criteria
Inclusion Criteria:
* Adult age 18 and older who consent to participate in the study
* Own a compatible iPhone or iPod Touch device running iOS 12.2 or above
* Be able to read and understand an official language of the country of participation
Exclusion Criteria:
* Age 17 years or younger
* Not a resident of the a country where the app is approved for use
* Not have a personal (i.e., not shared) iPhone (4s or newer running iOS 8.0 or later)
* Not be able to read and understand an official language of the country of participation
Study design
Enrollment target: 1000 participants
Age groups: adult, older_adult
Timeline
Starts: 2022-01-01
Estimated completion: 2027-01-31
Last updated: 2025-06-11
Interventions
Behavioral: Participant self-assessment surveysBehavioral: Psoriasis DrawBehavioral: Psoriasis Area PhotoBehavioral: Finger and Toe PhotosBehavioral: Digital Jar OpenBehavioral: 30 Second WalkOther: Psorcast mobile application
Primary outcomes
- • Results of participant self-assessment surveys (Through study completion, an average of 2 years)
- • Body surface area and location from the Psoriasis Draw assessment (Through study completion, an average of 2 years)
- • Computer vision features from Psoriasis Area Photo assessment (Through study completion, an average of 2 years)
Sponsor
Sage Bionetworks · other
With: Brigham and Women's Hospital, NYU Langone Health, University of Pennsylvania, Harvard Medical School (HMS and HSDM), New York University
Contacts & investigators
ContactSolveig K Sieberts, Ph.D · contact · psorcast@sagebase.org · 206-928-8266
ContactChristine Suver, Ph.D · contact · christine.suver@sagebase.org · 206-667-2128
InvestigatorSolveig Sieberts, Ph.D · principal_investigator, Sage Bionetworks
InvestigatorJose Scher, MD · principal_investigator, NYU Langone Medical Center
InvestigatorJoseph Merola, MD, MMSc · principal_investigator, Brigham and Women's Hospital & Harvard Medical School
All locations (1)
Sage BionetworksRecruiting
Seattle, Washington, United States