In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Mechanisms and Effects of Pallidal Deep Brain Stimulation on Levodopa Resistant Motor Signs in Parkinson's Disease; Udall Project 2 Aim 2A&C
About this study
This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC or RC DBS system to study the effects of globus pallidus internus, globus pallidus externus (GPi, GPe), and subthalamic nucleus (STN) DBS on: the wash-out and wash-in dynamics of motor behavior and local field potentials (LFPs) and correlations between fluctuations in gait and LFPs during activities of daily living (recorded over a minimum of 4 weeks). These experiments will elucidate the relationships between LFPs oscillations, lower limb function, postural control and gait performance.
Eligibility criteria
Inclusion Criteria:
* Receiving DBS therapy in GP for treatment of PD
* Implanted with Medtronic Percept DBS system
* At least 3 months since initial activation of the neurostimulator
* For the "At Home" experiment only: participants with DBS settings that are sensing compatible.
Exclusion Criteria:
* history of musculoskeletal disorders that significantly affects the ability to perform the motor tasks in the specific experiment in question
* history of dementia or cognitive impairment
* other significant neurological disorder as determined by the PI
* post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment
* lack of capacity to consent (as identified by MaCAT-CR)
Study design
Enrollment target: 36 participants
Age groups: child, adult, older_adult
Timeline
Starts: 2023-01-01
Estimated completion: 2028-03-01
Last updated: 2026-03-03
Interventions
Other: observational-- no intervention
Primary outcomes
- • Peak negative power (30 day)
- • Stride length (30 days)
- • Alpha power during standardized daily gait assessment (30 days)
Sponsor
University of Minnesota · other
Contacts & investigators
ContactColum Mackinnon, PhD · contact · cmackinn@umn.edu · 612-625-8938
All locations (1)
University of MinnesotaRecruiting
Minneapolis, Minnesota, United States