RecruitingRecruiting
Feasibility and Clinical Utility of Cell-free DNA (cfDNA) in Identifying Actionable Alterations and Minimal Residual Disease for Lymphoma Patients Across Community Centers in Texas
NCT05676450 · M.D. Anderson Cancer Center
In plain English
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About this study
Primary Objective:
• To determine the feasibility and clinical utility of ctDNA in identifying actionable alterations and minimal residual disease for lymphoma patients across community centers in Texas.
Secondary Objectives:
* To provide useful prognostic information before treatment, assess molecular response at interim time points and residual disease at the end of therapy, and identify tumor-specific mutations
* Levels of cfDNA and its association with both EFS and OS in patients receiving therapy
Eligibility criteria
Inclusion Criteria:
1. Male/female patients who are at least 18 years of age on the day of informed consent signing.
2. Patients must have a histologically documented diffuse large B-cell lymphoma requiring therapy.
3. Provision of written informed consent for the study.
4. Pregnant women not included
5. Cognitively impaired adults are not included.
Exclusion Criteria:
None
Study design
Enrollment target: 517 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2023-02-23
Estimated completion: 2026-08-31
Last updated: 2026-05-20
Interventions
Diagnostic Test: cell-free DNA
Primary outcomes
- • Overall Survival (OS) (through study completion; an average 1 year)
Sponsor
M.D. Anderson Cancer Center · other
Contacts & investigators
ContactChijioke Nze, MD · contact · CCNze@mdanderson.org · 832-729-1752
InvestigatorChijioke Nze, MD · principal_investigator, M.D. Anderson Cancer Center
All locations (2)
MD Anderson Cancer CenterRecruiting
Houston, Texas, United States
Cancer Therapy and Research Center at The UT Health Science Center at San AntonioRecruiting
San Antonio, Texas, United States