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Recruiting

Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics

NCT05694559 · M.D. Anderson Cancer Center
In plain English

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About this study
Primary Objectives: * To identify 300 Black families, at least one individual per family, eligible for genetic testing using our validated simple genetic risk screening tool (GRST) 1, via collaboration with trusted community organizations. For individuals eligible for genetic testing, we will counsel them about genetic testing, including reviewing GRST results, explaining why they are eligible for genetic testing as part of standard-of-care, explaining what this entails, offering on-site or remote genetic testing, and explaining that they will be connected to a genetic counselor if they have a pathogenic mutation (PV) of a variant of unknown significance (VUS), including resources for family cascade genetic testing. * To provide genetic testing to 150 Black individuals and families and provide genetic counseling and risk reduction resources to individuals with a PV or VUS, including cascade genetic testing for their family members.
Eligibility criteria
Inclusion Criteria: * Any participant over 18 years old who self-identifies as Black or African-American and signs an informed consent form, also referred to as the 'Permission to Contact' form, to be part of our study. Exclusion Criteria: None
Study design
Enrollment target: 1000 participants
Allocation: non_randomized
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2022-11-23
Estimated completion: 2027-02-02
Last updated: 2026-02-19
Interventions
Behavioral: Genetic Testing and CounselingBehavioral: Screening Form
Primary outcomes
  • genetic risk screening tool (GRST) questionnaire (through study completion; an average of 1 year.)
Sponsor
M.D. Anderson Cancer Center · other
Contacts & investigators
ContactBanu Arun, MD · contact · barun@mdanderson.org · 713-792-2817
InvestigatorBanu Arun, MD · principal_investigator, MD Anderson Cancer Cneter
All locations (1)
MD Anderson Cancer CenterRecruiting
Houston, Texas, United States
Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics · TrialPath