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Digestive Biobank for Exploring Microbiota-host Interactions

NCT05704413 · Assistance Publique - Hôpitaux de Paris
In plain English

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About this study
Inflammatory Bowel disease (Crohn, Ulcerative colitis) and colorectal cancer are frequent affections and the microbiota plays a major role in their physiopathology involving the immune system. In this setting, the interplay between gut microbiota and brain is still unexplored. To evaluate the interaction of the microbiota and the immune system with the host in these two chronic diseases, we aim to create a prospective biobank. A small amount of tissue will be taken during surgery. A whole blood, plasma and stoll samples will also be taken from the patient. All samples will be anonymized.
Eligibility criteria
Inclusion Criteria: * Ulcerative colitis, Crohn's disease or colorectal disease * Digestive resection with useless tissue available * Information consent signed Exclusion Criteria: \- Patients \< 18 years
Study design
Enrollment target: 500 participants
Age groups: adult, older_adult
Timeline
Starts: 2021-06-17
Estimated completion: 2026-09-17
Last updated: 2023-01-30
Primary outcomes
  • Relation between biological parameters and outcomes of digestive disease (IBD, CRC) (up to 12 months after the incusion)
Sponsor
Assistance Publique - Hôpitaux de Paris · other
Contacts & investigators
ContactJérémie LEFEVRE, PU-PH · contact · jeremie.lefevre@aphp.fr · +33 (0)1 49 28 25 63
ContactHarry SOKOL, PU-PH · contact · harry.sokol@aphp.fr · +33 (0)1 49 28 31 71
InvestigatorJérémie LEFEVRE, PU-PH · principal_investigator, Assistance Publique - Hôpitaux de Paris
All locations (1)
Service de Chirurgie Viscérale - Hôpital Saint AntoineRecruiting
Paris, France
Digestive Biobank for Exploring Microbiota-host Interactions · TrialPath