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Immune Function and the Progression to T1D
NCT05899439 · University of Florida
In plain English
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Official title
Immune Function and the Progression to Type 1 Diabetes:
About this study
Newly proposed studies will identify the inflammatory cues that draw immune cells into islets for disease initiation (Project 1); probe the motility of immune cells through inflamed vasculature to the target organ and antigen priming sites within secondary lymphatics (Project 2); and characterize the T1D-associated adaptive immune signatures in blood and immune tissues (Project 3).
The overall hypothesis of the renewed P01 states: 1) the impact of T1D-risk variants will vary by tissue, cell subset, and activation state, and 2) risk variants, cellular stress, and defects in immunologic pathways are key to engender the autoimmune destruction of pancreatic B-cells that results in T1D.
Eligibility criteria
Inclusion Criteria: able to have blood drawn -
Exclusion Criteria: none
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Study design
Enrollment target: 2800 participants
Age groups: child, adult, older_adult
Timeline
Starts: 2005-01-01
Estimated completion: 2085-01-01
Last updated: 2026-04-09
Interventions
Other: blood draw
Primary outcomes
- • the number of participants who become at risk for development of type 1 diabetes (through study completion, up to 25 years)
- • Genetic risk of type 1 diabetes (through study completion, up to 25 years)
Sponsor
University of Florida · other
With: Juvenile Diabetes Research Foundation, National Institute of Allergy and Infectious Diseases (NIAID)
Contacts & investigators
ContactJennifer L Hosford, MPH · contact · jennifer.hosford@peds.ufl.edu · 352-294-5759
ContactKieran McGrail · contact · mcgrail@pathology.ufl.edu · (352) 273-9299
All locations (3)
Kieran McGrailRecruiting
Gainesville, Florida, United States
The Ohio State UniversityRecruiting
Columbus, Ohio, United States
Baylor College of Medicine, Center for Research Advancement - Texas Children's HospitalRecruiting
Houston, Texas, United States