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A Registry for People With T-cell Lymphoma

NCT05978141 · Memorial Sloan Kettering Cancer Center
In plain English

Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.

Official title
The T-cell Lymphoma Master Repository (TCLMR): A Prospective Databank of Patients With T-cell Lymphoma With Clinical Annotation and Matched Tumor Specimens
About this study
The purpose of this registry study is to create a database-a collection of information-for better understanding T-cell lymphoma. Researchers will use the information from this database to learn more about how to improve outcomes for people with T-cell lymphoma.
Eligibility criteria
Inclusion Criteria: * Written informed consent * Adequate fresh or archival tumor biopsy or intent to obtain fresh tumor biopsy. * Pathologically-confirmed mature T- or natural killer (NK)-cell lymphoma meeting one of the following diagnostic criterion (based on WHO classification and NCCN guidelines): * T-cell prolymphocytic leukemia * T-cell large granular lymphocytic leukemia * Chronic lymphoproliferative disorder of NK cells * Aggressive NK-cell leukemia * Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma of childhood * Chronic active EBV infection of T- and NK-cell type, systemic form * Hydroa vacciniforme-like lymphoproliferative disorder * Adult T-cell leukemia/lymphoma * Extranodal NK/T-cell lymphoma, nasal type * Enteropathy-associated T-cell lymphoma * Monomorphic epitheliotropic intestinal T-cell lymphoma * Intestinal T-cell lymphoma, not otherwise specified (NOS) * Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract * Hepatosplenic T-cell lymphoma * Subcutaneous panniculitis-like T-cell lymphoma * Mycosis fungoides (limited to those with ≥ stage IB disease and those receiving active therapy) * Sézary syndrome * Primary cutaneous anaplastic large cell lymphoma (receiving systemic therapy) * Primary cutaneous Gamma-Delta T-cell lymphoma * Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma * Primary cutaneous acral CD8+ T-cell lymphoma (receiving systemic therapy) * Peripheral T-cell lymphoma, not otherwise specified * Angioimmunoblastic T-cell lymphoma * Follicular T-cell lymphoma * Nodal peripheral T-cell lymphoma with TFH phenotype * Anaplastic large cell lymphoma, ALK-positive * Anaplastic large cell lymphoma, ALK-negative * Breast-implant associated anaplastic large cell lymphoma. * NOTE: Patients with diagnoses of mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and/or primary cutaneous acral CD8+ T-cell lymphoma must be receiving systemic therapy. Exclusion Criteria: * Patients with of mycosis fungoides, primary cutaneous anaplastic large cell lymphoma, and/or primary cutaneous acral CD8+ T-cell lymphoma not receiving systemic therapy. * Inability to collect prospective data, measure response, or perform adequate follow-up assessments in the clinical judgment of the treating physician. NOTE: Repository participation does not exclude participation in clinical trials, nor does existing clinical trial participation exclude enrollment in the study herein outlined.
Study design
Enrollment target: 1000 participants
Age groups: child, adult, older_adult
Timeline
Starts: 2023-07-27
Estimated completion: 2030-07-27
Last updated: 2025-05-21
Interventions
Other: Optional Blood Sample and Nail Sample
Primary outcomes
  • Number of participants populating the T-cell Lymphoma Master Repository/TCLMR (10 years)
Sponsor
Memorial Sloan Kettering Cancer Center · other
Contacts & investigators
ContactSteven Horwitz, MD · contact · horwitzs@MSKCC.ORG · 646-608-2680
ContactAlison Moskowitz, MD · contact · moskowia@mskcc.org · 646-608-3726
InvestigatorSteven Horwitz, MD · principal_investigator, Memorial Sloan Kettering Cancer Center
All locations (26)
City of Hope Cancer Center (Data collection only)Not Yet Recruiting
Duarte, California, United States
UNIVERSITY OF CALIFORNIA SAN DIEGO (Data collection only)Not Yet Recruiting
San Diego, California, United States
University of California San Francisco (Data collection only)Not Yet Recruiting
San Francisco, California, United States
Stanford University Medical Center (Data collection only)Not Yet Recruiting
Stanford, California, United States
University of Colorado (Data Collection Only)Not Yet Recruiting
Aurora, Colorado, United States
Yale University (Data Collection Only)Not Yet Recruiting
New Haven, Connecticut, United States
University of Miami (Data Collection Only)Not Yet Recruiting
Miami, Florida, United States
Moffitt Cancer Center (Data Collection Only)Not Yet Recruiting
Tampa, Florida, United States
Emory University (Data Collection Only)Not Yet Recruiting
Atlanta, Georgia, United States
Northwestern Medicine (Data Collection)Not Yet Recruiting
Chicago, Illinois, United States
Massachusetts General Hospital (Data Collection Only)Not Yet Recruiting
Boston, Massachusetts, United States
Dana Farber Cancer Institute (Data Collection Only)Not Yet Recruiting
Boston, Massachusetts, United States
Mayo Clinic (Data Collection Only)Not Yet Recruiting
Rochester, Minnesota, United States
Washington University (Data Collection Only)Not Yet Recruiting
St Louis, Missouri, United States
University of Nebraska (Data collection only)Not Yet Recruiting
Omaha, Nebraska, United States
Memorial Sloan Kettering at Basking Ridge (All protocol activities)Recruiting
Basking Ridge, New Jersey, United States
Memorial Sloan Kettering Monmouth (All protocol activities)Recruiting
Middletown, New Jersey, United States
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (All protocol activities)Recruiting
Commack, New York, United States
Memorial Sloan Kettering Westchester (All protocol activities)Recruiting
Harrison, New York, United States
Weill Cornell Medical Center (Data Collection Only)Not Yet Recruiting
New York, New York, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)Recruiting
New York, New York, United States
Memorial Sloan Kettering Nassau (All protocol activities)Recruiting
Uniondale, New York, United States
Ohio State University (Data Collection Only)Not Yet Recruiting
Columbus, Ohio, United States
University of Pennsylvania (Data Collection Only)Not Yet Recruiting
Philadelphia, Pennsylvania, United States
Thomas Jefferson University Hospital (Data collection only)Not Yet Recruiting
Philadelphia, Pennsylvania, United States
MD Anderson Cancer Center (Data Collection Only)Not Yet Recruiting
Houston, Texas, United States
A Registry for People With T-cell Lymphoma · TrialPath