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Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer

NCT06038318 · Dana-Farber Cancer Institute
In plain English

Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.

About this study
In this sequential, multiple assignment, randomized trial participants will be randomly selected to participate in PRISM program sessions with a trained research coach either by text or by video sessions, or participants will use the PRISM mobile app program in a self-guided way. Randomization means the group participants are placed in will be decided by chance. All groups will continue to receive all the same care from primary medical, social work, and other care teams. In this two-stage study, participants will be randomly assigned to either the "app-only" (20% chance), "text" (40% chance) or "video" (40% chance) groups for the first stage. In the second stage, participants may be re-randomized again to the "app-only," or "text," groups, or will be referred to a specialty psychosocial support, social worker or counselor, based on responses to questionnaires. Participants randomized to the "app-only" group in the first stage will not be re-randomized. The research study procedures include screening for eligibility and completion of questionnaires. Participation in this research study is expected to last for up to 6 months. It is expected about 325 people will take part in this research study. The National Institute for Health (NIH) is funding this research study.
Eligibility criteria
Participants that have completed their main cancer-directed therapy at one of the study sites affiliated centers who meet all the eligibility criteria will be eligible for participation in this study. Inclusion Criteria: * All genders ≥ 12 and ≤ 25 years of age at baseline * Participant is able to speak English or Spanish language (for PRISM sessions) * Participant is able to read English or Spanish language (for completion of surveys) * Participant is cognitively able to participate in PRISM sessions and complete written questionnaires and surveys, as judged by the site investigator
Study design
Enrollment target: 325 participants
Allocation: randomized
Masking: none
Age groups: child, adult
Timeline
Starts: 2023-10-16
Estimated completion: 2027-05-01
Last updated: 2025-12-29
Interventions
Behavioral: PRISM Program Video CoachBehavioral: PRISM Program Text CoachBehavioral: mPRISM Program App
Primary outcomes
  • Connor Davidson Resilience Scale (CDRISC-10) Score (At 6 months)
Sponsor
Dana-Farber Cancer Institute · other
With: National Cancer Institute (NCI)
Contacts & investigators
ContactAbby Rosenberg, MD · contact · AbbyR_Rosenberg@DFCI.HARVARD.EDU · 206-987-6892
InvestigatorAbby Rosenberg, MD · principal_investigator, Dana-Farber Cancer Institute
All locations (2)
Boston Children's HospitalNot Yet Recruiting
Boston, Massachusetts, United States
Dana-Farber Cancer InstituteRecruiting
Boston, Massachusetts, United States
Promoting Resilience in Early Survivorship Among Adolescents and Young Adults With Cancer · TrialPath