RecruitingRecruiting
Genome Analysis Across Populations in Inflammatory Bowel Disease
NCT06042387 · Mount Sinai Hospital, Canada
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
Background:
Inflammatory bowel disease (IBD) is a chronic, and often disabling, disorder of the intestines characterized by dysregulation of mucosal immune response. Recent data suggests that the incidence and prevalence rates among all populations may be increasing due to constantly changing environmental exposures. The goal of the study is to identify susceptible genes that contribute to the pathogenesis of IBD in affected individuals.
Eligibility criteria
Inclusion Criteria:
* Subjects: diagnosed with Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis, IBD-undetermined)
* Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U))
* Healthy controls: no personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss
* Any age
Exclusion Criteria:
\- Subjects with other gastrointestinal conditions not meeting the above IBD or Healthy Control criteria
Study design
Enrollment target: 150 participants
Age groups: child, adult, older_adult
Timeline
Starts: 2022-05-01
Estimated completion: 2027-09
Last updated: 2025-03-25
Interventions
Genetic: Blood or saliva sample collection
Primary outcomes
- • Genomics studies across populations (2022-2027)
Sponsor
Mount Sinai Hospital, Canada · other
With: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Contacts & investigators
ContactJoanne Stempak, MSc · contact · joanne.stempak@sinaihealth.ca · 4165864800
ContactJenny Lee, MKin · contact · jenny.lee2@sinaihealth.ca · 416-586-4800
InvestigatorMark Silverberg, MD PhD · principal_investigator, Sinai Health System
All locations (1)
Sinai Health SystemRecruiting
Toronto, Ontario, Canada