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Communication Bridge 3 Study

NCT06191198 · University of Chicago
In plain English

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Official title
Communication Bridge: Optimizing an Evidence-based Intervention for Individuals With Primary Progressive Aphasia
About this study
Participants with a diagnosis of PPA and their actively-engaged care partners will be involved in the study for approximately 17 months. Each participant will receive a laptop equipped with the necessary applications and features for the study. Participants will receive up to 10 evaluations and 20 speech therapy sessions with a licensed speech therapist, as well as access to Communication Bridge, a personalized web application to practice home exercises that reinforce treatment strategies. There are no costs to participate in this study.
Eligibility criteria
Inclusion Criteria (person with PPA): 1. Meets diagnostic criteria for PPA based on neurologist and supporting medical assessments (extracted from medical records) 2. English as primary language used in daily communication activities (by self-report) 3. Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report) 4. Adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report) 5. Able to pass technology screening and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training) 6. Geriatric Depression Scale score ≤ 9 7. Mild-moderate PPA informed by a structured interview with a speech-language pathologist and a standardized testing battery. Inclusion Criteria (Co-enrolled communication partner): 1. 18+ years of age 2. English as primary language used in daily communication activities (by self-report) 3. Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report) 4. Able to pass technology screening\* and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training) Exclusion Criteria: * A dementia diagnosis other than Primary Progressive Aphasia * Participation is co-enrolled in an outside speech language therapy program during the study course. * Communication partners will be excluded if they have a pre-existing communication impairment that would affect study participation (e.g., aphasia, dementia) Medical records will be requested and reviewed to determine eligibility
Study design
Enrollment target: 200 participants
Allocation: randomized
Masking: triple
Age groups: adult, older_adult
Timeline
Starts: 2024-08-23
Estimated completion: 2028-07-15
Last updated: 2025-05-30
Interventions
Behavioral: Communication Bridge™Behavioral: Evidence-Based Impairment Focused
Primary outcomes
  • Change in Communication Participation Person Centered Goals (5 assessment time points through study completion (up to 18 months))
  • Change in Communication Participation (5 assessment time points through study completion (up to 18 months))
  • Montgomery Burden Inventory (MBI) (5 assessment time points through study completion (up to 18 months))
Sponsor
University of Chicago · other
With: Western University, Canada, National Institute on Aging (NIA)
Contacts & investigators
ContactMatthew Bona, MPH · contact · cbtrial@uchicago.edu · 773-702-1220
ContactEmily Cummings · contact · cbtrial@uchicago.edu · 773-702-1221
InvestigatorEmily Roglaski, PhD · principal_investigator, Professor of Neurology
All locations (1)
University of Chicago - American School BuildingRecruiting
Chicago, Illinois, United States
Communication Bridge 3 Study · TrialPath