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Inflammatory Bowel Disease Cohort in Nantes
NCT06256393 · Nantes University Hospital
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Cohorte Nantaise de Maladies Inflammatoires Chroniques Intestinales
About this study
The CELESTE cohort will be a prospective cohort of IBD patients followed up at Nantes University Hospital, Jules Verne Clinic (Nantes) and/or Confluent Private Hospital (Nantes). The multicentric nature of the cohort including a tertiary referral center and two secondary care centers is a major asset, enabling the enrolment of a broad spectrum of patients, from those naïve to any immunomodulatory treatment to those refractory to multiple biologic therapies.
It will be associated with a multi-omics biobank with the aim of identifying new cellular and molecular signatures of success of the therapeutic strategy at one year.
Eligibility criteria
Inclusion Criteria:
* Patients over 18 years of age;
* Patients with an established diagnosis of IBD: CD, UC, unclassified IBD or refractory chronic pouchitis;
* Patients with active disease requiring surgery or endoscopy, whether performed at diagnosis or prior to initiation of new therapy;
* Patients who have given written consent to participate in the study and to keep biological samples for research purposes
Exclusion Criteria:
* Patients refusing to participate in the cohort;
* Patients with chronic inflammatory bowel disease quiescent at inclusion;
* Patients with a contraindication to general anaesthesia;
* Vulnerable patients (under court protection, curators, guardians);
Study design
Enrollment target: 360 participants
Age groups: adult, older_adult
Timeline
Starts: 2025-02-04
Estimated completion: 2031-02
Last updated: 2025-02-10
Interventions
Other: Collection of biological samples
Primary outcomes
- • Proportion of patients who succeed in their therapeutic strategy (One year after inclusion)
Sponsor
Nantes University Hospital · other
Contacts & investigators
ContactCatherine Le Berre, MD · contact · catherine.leberre@chu-nantes.fr · +33240083152
All locations (3)
CHU de NantesRecruiting
Nantes, France
Clinique Jules VerneNot Yet Recruiting
Nantes, France
Hopital Privé du ConfluentNot Yet Recruiting
Nantes, France