← Back to searchRecruitingRecruiting
Effect of Continuing Versus Holding Metformin During Hospitalizations.
NCT06296836 · University of Illinois at Chicago
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Effect of Continuing Versus Holding Metformin During Hospitalizations to Internal Medicine on Glucose Control, Acidosis, Abdominal Symptoms, Length of Stay, and Mortality.
About this study
The purpose of this study is to determine what the effects of the routine practice of holding metformin in hospitalized patients with type 2 diabetes are on outcomes.
The objectives of this study are to determine how holding versus continuing metformin during hospitalization to an internal medicine service affects the incidences of lactic acidosis, mean anion gap, mean glucose levels, low and very high blood sugars, GI effects after discharge, lack of continuation of metformin upon discharge, mean glucose levels, lengths of stay, and 30-day mortality.
Eligibility criteria
Inclusion Criteria:
* Adult (18+ years of age)
* Admitted to an internal medicine service.
* On Metformin prior to admission.
Exclusion Criteria:
* Inability to take oral medications
* eGFR \< 30 ml/min/1.73 m2
* Dialysis
* Current Acidosis (pH \< 7.35) including diabetic ketoacidosis
* Child-Turcotte-Pugh class C hepatic cirrhosis
* Acute Decompensated Heart Failure
* Cognitively impaired and/or unable to consent
* Lack of or unwillingness to share contact information
* Pregnant women
Study design
Enrollment target: 300 participants
Allocation: randomized
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2025-01-21
Estimated completion: 2026-06-30
Last updated: 2025-02-27
Interventions
Drug: Metformin
Primary outcomes
- • Mean glucose levels (During hospitalization)
Sponsor
University of Illinois at Chicago · other
Contacts & investigators
ContactMathew Thambi, PharmD, MPH · contact · mthambi@uic.edu · 312-497-5540
ContactEmily Hanners, PharmD · contact · ehanne3@uic.edu · 312-355-0431
All locations (1)
University of Illinois at ChicagoRecruiting
Chicago, Illinois, United States