TrialPath
← Back to searchRecruiting

Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases

NCT06318585 · Istituto Auxologico Italiano
In plain English

Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.

Official title
Creazione di un Database Clinico Per lo Studio Della variabilità Fenotipica Nella Malattia Del Motoneurone
About this study
Study Description: Characterization of Motor Neuron Disease Phenotypes The goal of this observational study is to understand the clinical presentation of motor neuron disease (MND) in patients attending the Neurology Department of the Istituto Auxologico Italiano. The main questions it aims to answer are: * What are the specific clinical phenotypes associated with MND? * How can these phenotypes contribute to a better understanding of the disease's underlying mechanisms and improve prognostic accuracy? Participants will undergo: * Clinical evaluation using validated scales * Neurophysiological and neuroradiological instrumental assessment * Neuropsychological evaluation * Collection of biological materials for genetic screening and biomarker assessment, if necessary.
Eligibility criteria
Inclusion Criteria: * diagnosis of ALS or other motor neuron disease Exclusion Criteria: * refusal to participate to the study
Study design
Enrollment target: 200 participants
Age groups: adult, older_adult
Timeline
Starts: 2023-04-03
Estimated completion: 2026-12-31
Last updated: 2025-05-07
Primary outcomes
  • no. of patients with classic ALS (baseline (at diagnosis), at 1 year)
  • no. of patients with bulbar ALS (baseline (at diagnosis), at 1 year)
  • no. of patients with LMN phenotypes (flail arm, flail leg, PMA) (baseline (at diagnosis), at 1 year)
Sponsor
Istituto Auxologico Italiano · other
Contacts & investigators
ContactNicola Ticozzi, MD, PhD · contact · n.ticozzi@auxologico.it · +390261911
All locations (1)
Ospedale San LucaRecruiting
Milan, MI, Italy
Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases · TrialPath