RecruitingRecruiting
Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)
NCT06340646 · Washington University School of Medicine
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
The overall goal of the WU-PE-CGS is to build a rigorous, scientific evidence base for approaches that direct engagement of cancer patients and post-treatment cancer survivors as participants in cancer research, and to investigate the impact of directly engaging participants in decisions regarding returning of genomic results on participants' health and satisfaction. Participants in this study will be presented with the choice of types of genomic results to receive, and the Engagement Optimization Unit (EOU) will investigate the impact of this intervention on participant knowledge, expectations of benefit, personal utility, and decisional conflict.
Eligibility criteria
Eligibility Criteria:
* Patients with cholangiocarcinoma, multiple myeloma, or early onset colon or rectal cancer.
* If diagnosed with multiple myeloma, must be African-American.
* If diagnosed with colon or rectal cancer, must be African-American AND must be no older than 65 years old at the time of diagnosis.
* At least 18 years old
* Able to understand and willing to sign an IRB-approved written informed consent document
Study design
Enrollment target: 990 participants
Allocation: non_randomized
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2022-10-18
Estimated completion: 2027-01-31
Last updated: 2026-07-14
Interventions
Other: Return of Genetic Results: Biomarker information from cancer cellsOther: Return of Genetic Results: Inherited mutations related to cancerOther: Return of Genetic Results: Inherited mutations related to other medical issues
Primary outcomes
- • Participant knowledge of clinical genetic testing (Through completion of follow-up (estimated to be 5 years))
- • Participant expectations of benefit (Through completion of follow-up (estimated to be 5 years))
- • Participant personal utility (Through completion of follow-up (estimated to be 5 years))
Sponsor
Washington University School of Medicine · other
With: National Cancer Institute (NCI), The Foundation for Barnes-Jewish Hospital
Contacts & investigators
ContactGraham Colditz, M.D., DrPH, MPH · contact · colditzg@wustl.edu · 314-454-7939
ContactBettina Drake, Ph.D., MPH · contact · drakeb@wustl.edu · 314-747-4534
InvestigatorGraham Colditz, M.D., DrPH, MPH · principal_investigator, Washington University School of Medicine
All locations (1)
Washington University School of MedicineRecruiting
St Louis, Missouri, United States