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Identification of Metabolic Phenotypes Associated With Melanoma Metastasis

NCT06400550 · University of Texas Southwestern Medical Center
In plain English

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About this study
This is a single center, correlative study designed to assess metabolic features of melanoma tumors in patients. The study will involve the collection of melanoma tissue at the time of surgical biopsy or excision. All samples will be assessed by mass spectrometry for metabolomic analysis. A subset of patients will have received \[U-13C\]glucose infusions which will be utilized for isotope tracing metabolic analysis. Relevant clinical data (eg survival, metastasis) will be correlated with metabolic findings.
Eligibility criteria
Inclusion Criteria: * Patients with known or probable malignant melanoma lesions requiring surgical biopsy or excision. * Subjects of all races and ethnic origins over age 18. Exclusion Criteria: * Not a surgical candidate * Poorly controlled diabetes
Study design
Enrollment target: 400 participants
Age groups: adult, older_adult
Timeline
Starts: 2018-08-01
Estimated completion: 2028-08-01
Last updated: 2025-05-11
Primary outcomes
  • Glucose Utilisation in the TCA cycle (5 years)
Sponsor
University of Texas Southwestern Medical Center · other
Contacts & investigators
ContactAleuna Lee · contact · aleuna.lee@utsouthwestern.edu · 2146458968
InvestigatorJennifer Gill, MD, PhD · principal_investigator, University of Texas Southwestern Medical Center
All locations (1)
University of Texas Southwestern Medical CenterRecruiting
Dallas, Texas, United States