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Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia

NCT06446661 · University of Chicago
In plain English

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Official title
Improving Oral Chemotherapy Adherence in Maintenance for Adolescents and Adults With Acute Lymphoblastic Leukemia and T-cell Lymphoblastic Lymphoma Using Text Messages
About this study
The study will begin with a 28-day pilot phase where participants will be asked to complete questionnaires to determine if the text message intervention is acceptable to participants. In the efficacy phase, the study will compare adherence to oral mercaptopurine and methotrexate between those who receive the high intensity text message intervention and those who receive standard-of-care. It is believed that high-intensity text messages will increase patient adherence within cycle 1.
Eligibility criteria
Inclusion Criteria: * Age of 15 years or older at time of enrollment * Diagnosed with ALL or T-cell lymphoblastic lymphoma * Currently receiving treatment with pediatric-based regimen that includes maintenance with mercaptopurine and methotrexate (e.g., CALGB 10403). Study participation begins with the start of maintenance, so enrollment occurs prior to the start of maintenance. Patients in the pilot phase may have already started maintenance as long as the end of their maintenance therapy is scheduled to occur after the end of the 28-day pilot intervention. Exclusion Criteria: * Patient or caregiver who would receive text message reminders does not have a cell phone that receives text messages * Patient does not wish to participate * Text messages will be crafted in the patient's preferred language for medical communication, so English fluency is not an enrollment requirement.
Study design
Enrollment target: 48 participants
Allocation: non_randomized
Masking: none
Age groups: child, adult, older_adult
Timeline
Starts: 2026-05-19
Estimated completion: 2028-06-15
Last updated: 2026-07-10
Interventions
Other: High IntensityOther: No Text MessagingsOther: Low Intensity Text Messaging
Primary outcomes
  • To compare adherence to oral chemotherapy between study groups for first treatment cycle (Efficacy Phase) (84 days after completion of enrollment to efficacy phase of study)
  • Feasibility of text message interventions to improve adherence to oral chemotherapy (Pilot Phase) (28 days after completion of enrollment to pilot phase of study)
Sponsor
University of Chicago · other
Contacts & investigators
ContactClinical Trials Intake · contact · cancerclinicaltrials@bsd.uchicago.edu · 1-855-702-8222
InvestigatorAustin Wesevich · principal_investigator, University of Chicago
All locations (1)
University of Chicago Medicine Comprehensive Cancer CenterRecruiting
Chicago, Illinois, United States
Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia · TrialPath