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Comprehensive Yoga Therapy Based Lifestyle Prehabilitation Program for Women With Ovarian Cancer

NCT06545604 · M.D. Anderson Cancer Center
In plain English

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About this study
Primary Objectives: Primary Objective: to assess the feasibility of a CYT prehabilitation program in women with ovarian cancer scheduled to receive NACT and IDS. Feasibility criteria will include the percent of eligible patients who consent to participate (feasibility is defined as 30% of those approached and are eligible end up consenting) and study retention by the last follow-up (feasibility is defined as 60% of those undergoing surgery remaining in the study and providing some data at baseline and at last follow-up timepoint). Secondary Objectives: * Examine the effects of the CYT program on physical conditioning as assessed by the 2-minute step test (2MST) and sit to stand reps (30secSTS) compared with WLC. * Examine group differences in surgical outcomes including post op stay, readmission rate, post op morbidity, surgical site infection rate, , and time to first chemotherapy post operatively. * Examine group differences in patient-reported outcomes including QOL, fatigue, stress, sleep disturbances, mental health, social support, and mindfulness. * Examine if there are group differences in preoperative albumin level, vit D, magnesium levels. * Examine group differences and changes over time in microbiome biodiversity. * Examine group differences in body composition (sarcopenia) as measured by routine abdominal CT scans. * Explore the association between adherence to the components of CYT with ability to sustain behavior changes and between changes in lifestyle parameters with outcomes. This will be explored both within and across groups.
Eligibility criteria
Inclusion Criteria: 1. Women with stage III-IV epithelial ovarian, fallopian tube, primary peritonal cancer with recommendations for NACT/IDS at recruitment. 2. Able to read, write, and speak English. 3. 18 years of age or older. 4. Oriented to person, place, and time. 5. Access to internet connection. 6. Access to a tablet, laptop or computer or smart phone. 7. Access and ability to do virtual sessions. 9\. Plan for surgical intervention at MD Anderson Cancer Center 9. Performance status 0-2. Exclusion Criteria: 1. Have completed chemotherapy. 2. Any major thought disorder (e.g., schizophrenia, dementia). 3. Any major communication barriers that would preclude being able to complete the intervention (e.g., visually or hearing impaired). 4. Extreme mobility issues (e.g., unable to get in and out of a chair unassisted). 5. Have a regular mind-body practice or an established yoga practice.
Study design
Enrollment target: 55 participants
Allocation: randomized
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2025-06-06
Estimated completion: 2027-06-30
Last updated: 2026-07-29
Interventions
Other: Yoga Therapy for Nutritional, Physical, and Psychosocial PrehabilitationOther: Usual care supportive services including nutrition counseling per usual care
Primary outcomes
  • To assess the feasibility of a CYT prehabilitation program in women with ovarian cancer scheduled to receive NACT and IDS. (Through study completion; an average of 1 year)
Sponsor
M.D. Anderson Cancer Center · other
Contacts & investigators
ContactLois Ramondetta, MD · contact · lramonde@mdanderson.org · (713) 745-0307
InvestigatorLois Ramondetta, MD · principal_investigator, M.D. Anderson Cancer Center
All locations (1)
MD Anderson Cancer CenterRecruiting
Houston, Texas, United States
Comprehensive Yoga Therapy Based Lifestyle Prehabilitation Program for Women With Ovarian Cancer · TrialPath