RecruitingRecruiting
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.
NCT06697184 · BeOne Medicines
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
A Phase 1/2 Open-label Study to Investigate the Safety of Sonrotoclax Ramp-up Schedule(s) in Adult Patients With Hematological Malignancies.
About this study
This study will test the safety of novel sonrotoclax dosing with gradual increases of sonrotoclax dose over specified periods until the intended target daily dose is reached. The focus will be on tumor lysis syndrome (TLS) and related toxicity signals.
Sonrotoclax is a drug that works by blocking a protein called B-cell lymphoma-2 (BCL-2). When sonrotoclax blocks BCL-2 it slows down or stops the growth of tumor cells and helps them die. This can lead to improvements in patients with certain malignant diseases including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). The start of treatment with BCL-2 inhibitor requires a gradual ramp-up over the first weeks to avoid potential consequences of initial tumor cell breakage and the release of cell content in the bloodstream. Several ramp-up schedules have already been explored, and this study aims to optimize the dosing ramp-up schedule that may be beneficial to patients and caregivers. Zanubrutinib is a commercialized product that works by blocking a protein called Bruton's tyrosine kinase (BTK) and controlling the activity and survival of malignant B cells. Zanubrutinib has received approval in over 65 countries/regions worldwide for the treatment of adult participants with B-cell malignancies, including CLL and MCL.
This study will take place at multiple centers worldwide. The overall time to participate in this study is approximately 17 months for treatment-naïve (TN) CLL participants or approximately 32 months for relapsed/refractory (R/R) MCL participants.
Eligibility criteria
Inclusion Criteria:
1. Stable Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 2.
2. Adequate organ function and no very recent transfusion or blood growth factor
3. Participants of childbearing potential must be willing to use a highly effective method of birth control and refrain from egg donation for the duration of the study and for ≥ 7 days after the last dose of sonrotoclax or 1 month after the last dose of zanubrutinib, whichever is later.
Only for participants with Chronic Lymphocytic Leukemia (CLL):
4. Confirmed diagnosis of CLL, based on Hallek et al 2018, and requiring treatment due to certain features of their disease
5. At least 1 measurable lesion based on computed tomography (CT)/magnetic resonance imaging (MRI) and no history of prolymphocytic leukemia or Richter's transformation.
Only for participants with Mantle cell lymphoma (MCL):
6. Historically confirmed diagnosis of MCL based on the World Health Organization 2022 classification of Haematolymphoid Tumors (WHO-HEAM5) or based on International Consensus Classification (ICC).
7. Relapsed or refractory to the last line of therapy and have received at least 1 prior line of systemic therapy. Note: A line of therapy is considered ≥ 2 consecutive cycles of a systemic anticancer regimen. Patients with prior BTKi therapy should not have progressed during treatment or relapsed within 12 months after BTKi discontinuation.
8. Measurable disease defined as ≥ 1 nodal lesion that is \> 1.5 cm in longest diameter, or ≥ 1 extranodal lesion that is \> 1 cm in longest diameter.
Exclusion Criteria:
1. Participants unable to comply with the requirements of the protocol
2. Serologic status reflecting active viral hepatitis B virus (HBV) or hepatitis C virus (HCV) infection
3. Positive HIV serology (HIVAb) status unless certain conditions are met.
4. Participants with any major surgical procedure ≤ 28 days before first dose of study treatment
5. Prior systemic treatment for the CLL
6. Uncontrolled autoimmune hemolytic anemia or immune thrombocytopenia requiring treatment
7. Prior exposure to a BCL-2 inhibitor
NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Study design
Enrollment target: 258 participants
Allocation: non_randomized
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2025-01-23
Estimated completion: 2032-11-30
Last updated: 2026-06-08
Interventions
Drug: SonrotoclaxDrug: Zanubrutinib
Primary outcomes
- • Number of Participants who Experience Tumor Lysis Syndrome (TLS) (Up to approximately 4 months)
Sponsor
BeOne Medicines · industry
Contacts & investigators
ContactStudy Director · contact · clinicaltrials@beonemed.com · 1.877.828.5568
ContactStudy Director · contact
InvestigatorStudy Director · study_director, BeOne Medicines
All locations (17)
Moffitt Cancer CenterActive Not Recruiting
Tampa, Florida, United States
Fort Wayne Medical Oncology and HematologyActive Not Recruiting
Fort Wayne, Indiana, United States
The University of Kansas Cancer CenterActive Not Recruiting
Westwood, Kansas, United States
Dana Farber Cancer InstituteActive Not Recruiting
Boston, Massachusetts, United States
Washington University School of MedicineActive Not Recruiting
St Louis, Missouri, United States
Fred Hutchinson Cancer Research CenterActive Not Recruiting
Seattle, Washington, United States
Blacktown Cancer and Haematology CentreRecruiting
Blacktown, New South Wales, Australia
Genesiscare St AndrewsRecruiting
Adelaide, South Australia, Australia
Cabrini Hospital MalvernRecruiting
Malvern, Victoria, Australia
The Alfred HospitalRecruiting
Melbourne, Victoria, Australia
Rockingham HospitalRecruiting
Cooloongup, Western Australia, Australia
Linear Clinical ResearchRecruiting
Nedlands, Western Australia, Australia
Chu DijonActive Not Recruiting
Dijon, France
Chu Montpellier Hopital Saint EloiActive Not Recruiting
Montpellier, France
Iuct OncopoleActive Not Recruiting
Toulouse, France
Queen Elizabeth HospitalActive Not Recruiting
Birmingham, United Kingdom
St Jamess University HospitalActive Not Recruiting
Leeds, United Kingdom