RecruitingRecruiting
Working Memory Training in Patients with Mild Cognitive Impairment
NCT06734286 · St. Joseph's Hospital and Medical Center, Phoenix
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
CogMed Intervention Targeting Working Memory in Patients with Mild Cognitive Impairment
About this study
The goal of this study is to conduct a pilot clinical trial aimed at comparing the effects of CogMed intervention plus Treatment As Usual (TAU) versus TAU alone in patients with Mild Cognitive Impairment (MCI). Based on our preliminary data from brain health program, the primary hypothesis is that the CogMed intervention may improve the CogMed measures and possibly working memory. This may improve sense of self-efficacy and lead to a decrease in perceived stress, thereby demonstrating possible transfer of cognitive benefits to biobehavioral construct of perceived stress. Additionally, the study aims to demonstrate the feasibility of collecting p-Tau 217, a blood based Alzheimer's Disease biomarker, from MCI patients. Though no significant changes in pTau 217 are expected due to the short duration of the study, the goal is to successfully recruit 10 MCI patients (5 in the intervention group and 5 in the control group) who are willing to undergo blood draws for p-Tau 217 level determination.
Eligibility criteria
Inclusion Criteria:
1. Male or female outpatients ages ≥ 50 years;
2. Meet Mayo Clinic Criteria for MCI. (Patients with mild cognitive impairment)
3. Access to the internet through computer
4. A proficiency in speaking and reading English or having a family member who is proficient in reading and speaking English and is willing to serve as a translator.
5. Vision and hearing must be sufficient to comply with study procedures.
Exclusion Criteria:
1. Mini Mental State Exam (MMSE) score less than 19 or patients diagnosed with moderate or severe dementia by a clinician.
2. In the opinion of the investigator, participation would not be in the best interest of the subject.
Study design
Enrollment target: 10 participants
Allocation: randomized
Masking: single
Age groups: adult, older_adult
Timeline
Starts: 2024-09-16
Estimated completion: 2025-09-30
Last updated: 2024-12-16
Interventions
Other: CogMed
Primary outcomes
- • Working Memory as measured by the WAIS-IV Digit Span Forward/Backward (Will be assessed at baseline and again at a 3-month follow-up following the intervention period.)
- • Working Memory as measured by the TMT-B (Will be assessed at baseline and again at a 3-month follow-up following the intervention period.)
- • Working Memory as measured by Category Fluency Test (Will be assessed at baseline and again at a 3-month follow-up following the intervention period.)
Sponsor
St. Joseph's Hospital and Medical Center, Phoenix · other
With: Barrow Neurological Foundation, Barrow Neurological Institute
Contacts & investigators
ContactYonas E Geda, M.D, MSc · contact · yonas.geda@commonspirit.org · 833-233-3073
ContactGeetika Chahal, MBBS · contact · geetika.chahal@commonspirit.org · 602-406-7240
InvestigatorYonas E Geda, M.D, MSc · principal_investigator, Barrow Neurological Institute, Alzheimer's Disease and Cognitive Disorders Division
All locations (1)
Barrow Neurological Institute, Division of Alzheimer's DiseaseRecruiting
Phoenix, Arizona, United States