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Recruiting

Bronchoscopic Lung Ablation of Small Thoracic Tumors: the Blastt Registry

NCT06840288 · M.D. Anderson Cancer Center
In plain English

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About this study
A. To aggregate, integrate, and analyze data facilitating the study of MD Anderson participants with a known diagnosis of lung cancer or metastases to the lungs who undergo robotic assisted bronchoscopic ablation of peripheral tumors. B. To assess the intra-operative, peri-operative, and long-term safety outcomes of robotic assisted bronchoscopic ablation of peripheral lung tumors. C. To evaluate different oncologic outcomes including local tumor progression (LTP) by RECIST criteria, local tumor progression free survival (LTPFS), progression free-survival (PFS), disease (cancer) specific survival (DSS), and overall survival (OS). D. To provide a deeper understanding of the evolution of radiographic findings of bronchoscopically ablated lung tumors over time. E. To evaluate tumor and participant-related risk factors that may be associated with safety (bleeding, pneumothorax, and local infection) and oncologic outcomes (LTPFS, PFS, DSS, and OS).
Eligibility criteria
Inclusion Criteria: Patients with peripheral lung tumors (primary or metastatic) that have been or will be ablated via robotic bronchoscopy. Exclusion Criteria: Patients with planned bronchoscopic ablations of peripheral lung tumors that were aborted for technical reasons (ablation was not completed).
Study design
Enrollment target: 250 participants
Age groups: adult, older_adult
Timeline
Starts: 2025-02-19
Estimated completion: 2036-12-31
Last updated: 2026-06-12
Primary outcomes
  • To aggregate, integrate, and analyze data facilitating the study of MD Anderson patients with a known diagnosis of lung cancer or metastases to the lungs who undergo robotic assisted bronchoscopic ablation of peripheral tumors. (Through study completion, an average of 1 year.)
Sponsor
M.D. Anderson Cancer Center · other
Contacts & investigators
ContactRoberto F Casal, MD · contact · rfcasal@mdanderson.org · (713) 792-6238
InvestigatorRoberto F Casal, MD · principal_investigator, Prinicipal Investigator
All locations (1)
MD Anderson Cancer CenterRecruiting
Houston, Texas, United States
Bronchoscopic Lung Ablation of Small Thoracic Tumors: the Blastt Registry · TrialPath