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Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19
NCT06864156 · Instituto Nacional de Rehabilitacion
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
About this study
At the moment, the number of people with long COVID is unkown because there is still no effective diagnosis. This is why is very important to analyze the most common symptoms, which are: depression, anxiety and fatigue. This project seeks to analyze some blood components of people with long COVID, such as microRNAs and vitamin B12, in order to identify the body processes that changed after COVID-19 and thereby design better therapies and diagnostic methods focused on each of them.
The hypothesis is that the expression of miR-21, -146a and -155 will be overexpressed as well as there will be a deficiency of vitamin B12 in serum in subjects suffering from long COVID with neurological symptoms of depression, anxiety and fatigue.
Eligibility criteria
Inclusion Criteria:
* Subjects with confirmed diagnosis of COVID-19 by SARS-CoV-2 infection by PCR or antigen testing.
* With presence of neurological symptoms of depression, anxiety and fatigue associated with COVID-19 after three months from the first day of acute infection symptoms.
Exclusion Criteria:
* Subjects who have presented symptoms of acute infection in the last twelve weeks.
* Subjects who present diagnostic premorbid neurological alterations.
* Subjects who do not have at least 2 doses of COVID-19 vaccine, with last application date equal or older than 3 months.
Study design
Enrollment target: 20 participants
Age groups: adult, older_adult
Timeline
Starts: 2025-02-18
Estimated completion: 2025-07
Last updated: 2025-03-07
Primary outcomes
- • Change of microRNA expression between long COVID group and control group (immediately after the blood extraction)
- • Change of vitamin B12 concentration between long COVID group and control group (immediately after the blood extraction)
- • Link the expression of microRNAs with the score obtained in the instruments to evaluate depression, anxiety and fatigue (immediately after the blood extraction)
Sponsor
Instituto Nacional de Rehabilitacion · other_gov
All locations (1)
Instituto Nacional de RehabilitaciónRecruiting
Mexico City, Mexico City, Mexico