RecruitingRecruiting
The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors
NCT06938555 · Arizona State University
In plain English
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Official title
The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors (RESTORE)
About this study
The purpose of this innovative, remotely-delivered pilot randomized controlled trial (RCT) is to explore the use of an 8-week prolonged nightly fasting (PNF) intervention, as compared to a Health Education-Only (HED-Only) control condition, among ethnically and racially diverse (≥50% Black, Hispanic, and/or Native American) breast cancer survivors (BCSs) with cancer-related cognitive impairment (CRCI) to examine changes in cognitive function, sleep, insomnia and health-related quality of life (i.e., mental and physical). Additionally, intervention feasibility will be assessed among the PNF participants. All participants will receive health education (HED) throughout. BCSs living with CRCI (N=60) will be recruited nationwide and randomized 1:1 into the PNF or HED-Only groups. Linear mixed models will be used to compare outcome changes in the PNF group compared to HED-Only group (Aims 1-3); descriptive and qualitative analyses will be used in the Exploratory Aim.
Eligibility criteria
Inclusion Criteria:
1. ≥18 years old
2. diagnosed with breast cancer (all stages included)
3. ≥3 months post neoadjuvant or adjuvant chemotherapy (maintenance or palliative systemic therapy is included)
4. score ≤30 or lower on the Patient Reported Outcome Measurement Information System Cognitive Function Short Form 8a (sr-CRCI)
5. able to speak/understand English
6. have access to a computer and Wi-Fi
7. live within the United States
8. Identifies as female
9. willing and able to fully participate in the study
Exclusion Criteria:
1. type 1 diabetes
2. actively enrolled in formal diet/weight loss program
3. previous bariatric surgery
4. eating disorder history
5. night shift work
6. pregnant, breast feeding, or trying to get pregnant
7. dementia, psychological, psychiatric, or neurological diagnoses
8. active brain or central nervous system disease
9. prior or current use of memory enhancing medications
10. history or current brain radiation
11. frequently fasting for 12+ hours every night
13\) history of hypoglycemia 14) depression screening on PHQ9 with a score of 20 or greater across all 9 questions OR anything other than 0 on question 9
Study design
Enrollment target: 60 participants
Allocation: randomized
Masking: single
Age groups: adult, older_adult
Timeline
Starts: 2025-03-18
Estimated completion: 2026-12-31
Last updated: 2026-05-01
Interventions
Behavioral: Prolonged Nightly FastingBehavioral: Health Education Videos
Primary outcomes
- • Examine PNF-induced changes in cognitive function as compared to the HED-Only control condition. (Baseline (T1) and 8-week end point (T2) data collection)
- • Examine PNF-induced changes in cognitive function as compared to the HED-Only control condition. (Baseline (T1) and 8-week end point (T2) data collection)
Sponsor
Arizona State University · other
With: Mayo Clinic
Contacts & investigators
ContactJen Project Coordinator · contact · restorestudy@asu.edu · 602-496-8248
ContactDorothy Sears, PhD · contact · Dorothy.Sears@asu.edu · 602-496-3351
InvestigatorDorothy Sears, PhD · principal_investigator, Arizona State University
InvestigatorSarah James, MD, PhD · principal_investigator, Mayo Clinic
All locations (1)
Arizona State UniversityRecruiting
Phoenix, Arizona, United States