RecruitingRecruiting
Respiratory Virus Infections in Acute Heart Failure
NCT06967441 · Seoul National University Bundang Hospital
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Respiratory Virus Infections in Hospitalized Patients With Acute Heart Failure Syndrome: A Prospective Multi-center Observational Study
About this study
Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.
The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.
Eligibility criteria
Inclusion Criteria:
* Adult aged 19 years or older admitted to the cardiology department with acute heart failure
* NT-proBNP \>300 pg/mL
* Clinician judgement of possible respiratory viral infection (fever \>38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP \>5 mg/dL)
* Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons
Exclusion Criteria:
* Patients with a clear other cause of acute heart failure (ex. ACS, bradycardia requiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP \>180mmHg or DBP \>110mmHg), haemoglobin \<7g/dL or AHF precipitated by medication non-adherence)
* If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
* If there is a clear other source of infection that can explain the fever
Study design
Enrollment target: 360 participants
Age groups: adult, older_adult
Timeline
Starts: 2025-04-07
Estimated completion: 2028-12-31
Last updated: 2026-03-11
Primary outcomes
- • Respiratory virus PCR detection rate (Within 3 days of admission)
Sponsor
Minjae Yoon · other
With: Samsung Medical Center, Seoul St. Mary's Hospital
Contacts & investigators
ContactMinjae Yoon, MD · contact · minjae1677@gmail.com · +82-10-6334-1917
All locations (3)
Seoul National University Bundang HospitalRecruiting
Seongnam-si, Gyeonggi-do, South Korea
Samsung medical centerRecruiting
Seoul, South Korea
Seoul ST. Mary's HospitalRecruiting
Seoul, South Korea