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Community-based Approach to Lowering Stress Through Mindfulness
NCT06987799 · Northwestern University
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Addressing Depression for African American Adults With Hypertension: Applying Community-Engaged Implementation Science
About this study
The goal of this clinical trial is to test a culturally adapted mindfulness-based stress reduction intervention in a community setting for African American adults with high blood pressure (hypertension) and depression. The main questions it aims to answer are:
* Does participation in a culturally adapted mindfulness-based intervention improve depressive symptoms?
* Does participation in a culturally adapted mindfulness-based intervention improve blood pressure control?
* Is the intervention acceptable, appropriate, and feasible as delivered in a community setting?
Participants will:
* Participate in an 8-week group-based mindfulness intervention (CALM-Chicago). During intervention sessions, participants will learn about mindfulness and stress management and complete mindfulness-based activities, such as guided deep breathing and meditation.
* Complete surveys online
* Have their blood pressure measured with a non-invasive blood pressure cuff
* Attend 1 focus group (optional)
Eligibility criteria
Inclusion Criteria:
* ≥18 years old
* Lives, works, or spends much of their time in the South Side of Chicago neighborhood
* Self-reports diagnosis of hypertension or high blood pressure by a clinician
* Endorses elevated depressive symptoms as Patient Health Questionnaire (PHQ)-9 scores ≥10
* Not taking antidepressant medication or stable on antidepressant medication for ≥6 months as self-reported
Exclusion Criteria:
* \<18 years old
* Severe mental illness (e.g., bipolar disorder, psychosis)
* Current suicidal ideation (PHQ-9 item 9) or recent (past 6 months) suicide attempt
* Unable to provide informed consent or complete study activities in English
Study design
Enrollment target: 60 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2025-09-10
Estimated completion: 2028-05-31
Last updated: 2026-04-13
Interventions
Behavioral: Mindfulness-Based Stress Reduction (MBSR; CALM-Chicago Study)
Primary outcomes
- • Effectiveness: Depressive Symptom Response (From enrollment to the end of treatment at 8 weeks)
- • Effectiveness: Systolic Blood Pressure Response (From enrollment to the end of treatment at 8 weeks)
- • Implementation: Acceptability (Assessed every 6 during the clinical trial enrollment and follow-up for up to 3 years)
Sponsor
Northwestern University · other
With: National Heart, Lung, and Blood Institute (NHLBI), Total Resource Community Development Organization (TRCDO)
Contacts & investigators
ContactAsia Ellis, BA · contact · asia.ellis@northwestern.edu · 13125033569
InvestigatorAllison J Carroll, PhD · principal_investigator, Northwestern University
All locations (1)
The Salvation Army Ray and Joan Kroc Corps Community Center ChicagoRecruiting
Chicago, Illinois, United States