← Back to searchRecruitingRecruiting
Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
NCT07090161 · Vanda Pharmaceuticals
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
About this study
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Iloperidone for the Treatment of Participants with Uncontrolled Hypertension
Eligibility criteria
Inclusion Criteria:
* SiSBP \>/= 130 mmHg despite \>8 weeks treatment w/ 1 or more antihypertensive therapies
Exclusion Criteria:
* Confirmed Grade 3/severe hypertension (SiSBP \>/= 180 mmHg, SiDBP \>/= 120 mmHg), unstable cardiac disease, renal insufficiency
Study design
Enrollment target: 240 participants
Allocation: randomized
Masking: quadruple
Age groups: adult, older_adult
Timeline
Starts: 2025-09-15
Estimated completion: 2026-11
Last updated: 2026-02-27
Interventions
Drug: iloperidoneDrug: Placebo
Primary outcomes
- • Change from baseline to treatment week 4 in SiSBP (screening to treatment week 4)
Sponsor
Vanda Pharmaceuticals · industry
Contacts & investigators
ContactVanda Pharmaceuticals, Inc. · contact · clinicaltrials@vandapharma.com · 202-734-3400
All locations (28)
Vanda Investigative SiteNot Yet Recruiting
Phoenix, Arizona, United States
Vanda Investigative SiteRecruiting
Tempe, Arizona, United States
Vanda Investigative SiteNot Yet Recruiting
Tucson, Arizona, United States
Vanda Investigative SiteRecruiting
Chula Vista, California, United States
Vanda Investigative SiteRecruiting
Dublin, California, United States
Vanda Investigative SiteNot Yet Recruiting
Valencia, California, United States
Vanda Investigative SiteRecruiting
Walnut Creek, California, United States
Vanda Investigative SiteNot Yet Recruiting
Doral, Florida, United States
Vanda Investigative SiteRecruiting
Fort Myers, Florida, United States
Vanda Investigative SiteRecruiting
Columbus, Georgia, United States
Vanda Investigative SiteRecruiting
Oak Brook, Illinois, United States
Vanda Investigative SiteRecruiting
Tinley Park, Illinois, United States
Vanda Investigative SiteRecruiting
El Dorado, Kansas, United States
Vanda Investigative SiteRecruiting
Wichita, Kansas, United States
Vanda Investigative SiteRecruiting
Lexington, Kentucky, United States
Vanda Investigative SiteRecruiting
Hazelwood, Missouri, United States
Vanda Investigative SiteNot Yet Recruiting
Las Vegas, Nevada, United States
Vanda Investigative SiteNot Yet Recruiting
Mount Kisco, New York, United States
Vanda Investigative SiteNot Yet Recruiting
Rochester, New York, United States
Vanda Investigative SiteRecruiting
Kinston, North Carolina, United States
Vanda Investigative SiteRecruiting
Cincinnati, Ohio, United States
Vanda Investigative SiteRecruiting
Norman, Oklahoma, United States
Vanda Investigative SiteNot Yet Recruiting
Oklahoma City, Oklahoma, United States
Vanda Investigative SiteRecruiting
Charleston, South Carolina, United States
Vanda Investigative SiteNot Yet Recruiting
Carrollton, Texas, United States
Vanda Investigative SiteNot Yet Recruiting
Salt Lake City, Utah, United States
Vanda Investigative SiteRecruiting
Burke, Virginia, United States
Vanda Investigative SiteRecruiting
Norfolk, Virginia, United States