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Open-label Extension Study in Participants With Early Alzheimer's Disease

NCT07105709 · GlaxoSmithKline
In plain English

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Official title
A Multi-Centre, Single Arm, Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of GSK4527226 (AL101) in Participants With Early Alzheimer's Disease
About this study
The study medicine GSK4527226 is being studied in participants with Alzheimer's Disease (AD) in study 219867 (the parent study, NCT06079190). This new study is an extension of that parent study called an open-label extension (OLE). An OLE is a clinical trial where all participants receive the same study medicine. Participants must already be in study 219867 to be able to take part in this study. This study will assess the long-term safety and efficacy of GSK4527226 in participants with early AD (including mild cognitive impairment \[MCI\] and mild dementia due to AD) who have completed the parent study.
Eligibility criteria
Inclusion Criteria: * Completion of the Treatment Period in the parent study (NCT06079190). * Participants may have missed doses during the Treatment Period or may be on a temporary dose suspension but must not have been permanently discontinued early from study intervention or withdrawn from the parent study. * Willing and able to give informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF). * Availability of an adult person who has frequent and sufficient contact with the participant, is able to provide accurate information regarding the participant's cognitive and functional abilities, agrees to provide information at clinic visits, and signs the study partner ICF. * A female participant is eligible to participate if she is not pregnant or breastfeeding, and if of childbearing potential follows contraception requirements outlined in the protocol. * A male participant is eligible to participate if he follows contraception requirements outlined in the protocol. Exclusion Criteria: * QT interval corrected (QTc) assessment at Day 1 that meets the stopping criteria described in the protocol. * Participant is taking or will be starting a prohibited medication described in the protocol. * Evidence of any Amyloid related imaging abnormalities (ARIA) or cerebral macrohemorrhage that meets the permanent discontinuation criteria described in the protocol. * Other newly identified intracranial hemorrhage aneurysm, vascular malformation, infective lesion, space occupying lesion or brain tumor, or other Magnetic resonance imaging (MRI) findings contraindicating participation in the study. * Newly identified infection(s) that may affect the Central nervous system (CNS). * New diagnosis of moderate to severe alcohol and/or substance use disorder. * Change in participant's ability to tolerate MRI procedures, contraindication to MRI, or any other clinical history or examination finding that would pose a potential hazard in combination with MRI. * Newly diagnosed cancer. * Newly identified severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric, human, or humanized antibodies or fusion proteins. * Newly identified genetic predisposition for clotting disorder or hemorrhagic disease. * Any other clinically significant change in health status (which, in the opinion of the investigator, would make the participant unsuitable for participation in the OLE study.
Study design
Enrollment target: 220 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2025-08-14
Estimated completion: 2028-12-08
Last updated: 2026-02-02
Interventions
Drug: GSK4527226
Primary outcomes
  • Number of Participants with Treatment Emergent Adverse Events (AEs) during the OLE (Up to 112 Weeks)
  • Number of Participants with Adverse Event of Special Interest (AESIs) during the OLE (Up to 112 Weeks)
  • Number of Participants with Serious Adverse Events (SAEs) during the OLE (Up to 112 Weeks)
Sponsor
GlaxoSmithKline · industry
With: Alector Inc.
Contacts & investigators
ContactUS GSK Clinical Trials Call Center · contact · GSKClinicalSupportHD@gsk.com · 877-379-3718
ContactEU GSK Clinical Trials Call Center · contact · GSKClinicalSupportHD@gsk.com · +44 (0) 20 89904466
InvestigatorGSK Clinical Trials · study_director, GlaxoSmithKline
All locations (33)
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Maitland, Florida, United States
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Miami, Florida, United States
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Stuart, Florida, United States
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Toms River, New Jersey, United States
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Staten Island, New York, United States
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Matthews, North Carolina, United States
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Oklahoma City, Oklahoma, United States
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Houston, Texas, United States
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Fairfax, Virginia, United States
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Ciudad Autonoma de Buenos Aire, Argentina
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Ciudad Autonoma de Bueno, Argentina
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Macquarie Park, New South Wales, Australia
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Nedlands, Western Australia, Australia
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Ottawa, Ontario, Canada
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Peterborough, Ontario, Canada
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Toronto, Ontario, Canada
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Greenfield Park, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Oulu, Finland
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Bergen, Norway
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Oslo, Norway
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Junggu, South Korea
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Barcelona, Spain
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Gothenburg, Sweden
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Malmo, Sweden
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Stockholm, Sweden
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Tainan, Taiwan
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Taoyuan District, Taiwan
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Birmingham, United Kingdom
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Bristol, United Kingdom
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London, United Kingdom
Open-label Extension Study in Participants With Early Alzheimer's Disease · TrialPath