Treatment for PTSD and Tinnitus

NCT07106593 · The University of Texas Health Science Center at San Antonio

Recruiting

In plain English

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Official title

Treatment of TBI-Related Tinnitus and Comorbid PTSD: Examination of Neurobiological Markers Related to Symptom Improvement

About this study

After consenting to this study, study participants will be asked to speak with a study staff member about stressful or traumatic experiences, complete hearing assessments and questionnaires about exposure to traumatic events, PTSD symptoms, mental and physical health problems, such as depression and substance use, head injuries, and tinnitus. Participants who are able and willing may be asked to provide functional magnetic resonance imaging (MRI) scans before and after treatment. Participants will receive treatment for tinnitus and posttraumatic stress disorder (PTSD) in one of two ways: Cognitive Processing Therapy (CPT) first and then Cognitive Behavioral Therapy for Tinnitus (CBT-t) OR CBT-t first, followed by CPT.

Eligibility criteria

Inclusion Criteria: * Adult male and female active duty military personnel and veterans seeking treatment for PTSD * Diagnosis of PTSD * Person has experienced at least one mild traumatic brain injury (concussion) * Ability to speak and read English * Stable on any psychotropic medications * Meets criteria for chronic subjective and bothersome tinnitus * Chronic tinnitus is at least possibly related to head injury Exclusion Criteria: * Currently receiving other talk therapies * Severe hearing loss that would prevent the participant from benefiting from therapy * Current severe suicidal ideation * Psychiatric hospitalization in the last 12 months * Moderate to severe substance use that would prevent the participant form benefiting from therapy * Current manic episode or psychotic symptoms requiring immediate stabilization or hospitalization * Significant cognitive impairment * Moderate to severe brain damage * Neurobiological disorders * Temporomandibular joint disorders and/or Meniere's disease that cause acute pain

Study design

Enrollment target: 160 participants

Allocation: randomized

Masking: single

Age groups: adult, older_adult

Timeline

Starts: 2025-08-08

Estimated completion: 2028-08

Last updated: 2025-08-13

Interventions

Behavioral: Cognitive Processing TherapyBehavioral: CBT-t

Primary outcomes

• PTSD Checklist (Baseline to 6-Month Follow-Up (approximately12 months))
• Tinnitus Functional Index (Baseline to 6-Month Follow-Up (approximately12 months))

Sponsor

The University of Texas Health Science Center at San Antonio · other

With: University of Illinois at Urbana-Champaign

Contacts & investigators

ContactAmanda Flores, BA · contact · floresa13@uthscsa.edu · 210-562-6726

InvestigatorJohn Moring, PhD · principal_investigator, The University of Texas Health Science Center at San Antonio

All locations (1)

The University of Texas Health Science Center at San AntonioRecruiting

San Antonio, Texas, United States

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