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Ecological Momentary Intervention for Reward in Anhedonia

NCT07155941 · Philipps University Marburg
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About this study
Anhedonia, the diminished ability to experience positive emotions such as pleasure, is a clinically relevant condition central to depression and frequently observed across a range of other psychological disorders including anxiety disorders or chronic stress. Despite its prevalence and impact on quality of life, effective interventions specifically targeting anhedonia remain limited. Standard cognitive-behavioral therapies (CBT) often reduce negative affect (e.g., sadness, anxiety) but tend to be less effective in enhancing positive affect. Moreover, anhedonia has been proposed as a potential limiting factor in the efficacy of exposure-based treatments for anxiety disorders, underscoring the need for low-threshold interventions that directly target reward-related deficits. At the core of anhedonia lies impaired reward processing, which involves multiple phases: (1) reward anticipation (wanting), (2) reward consumption (liking), and (3) reward-based learning. Individuals with elevated anhedonia often show deficits across these domains, leading to reduced engagement in rewarding activities and motivational impairments. Therefore, effective interventions should aim to strengthen these specific facets of reward functioning. Emerging approaches such as Positive Affect Treatment (PAT) have demonstrated promising effects by combining components like positive mental imagery, savoring, self-reinforcement (i.e., taking ownership of positive experiences), and cognitive reframing (e.g., silver lining techniques). Complementary evidence suggests that gratitude-based interventions can enhance well-being and buffer against stress, based on the idea that gratitude and negative affect are partially incompatible. Building on these findings, the current study tests a two-week ecological momentary intervention (EMI) designed to enhance reward processing and reduce anhedonia in daily life. The intervention is delivered via the smartphone app m-Path and comprises three brief training units per day. These include a combination of audio-guided exercises and ecological momentary assessments (EMA) capturing mood, activity, and psychological symptoms. The exercises target positive mental imagery, savoring, gratitude, silver lining, and taking ownership of positive experiences-each mapped onto distinct components of reward processing. EMI formats offer the advantage of flexibility and integration into everyday contexts without requiring direct clinician contact. Participants are randomly assigned to either the reward-focused intervention group or an active control group. The control group receives a structurally equivalent two-week training consisting of progressive muscle relaxation (PMR) exercises, also delivered via the m-Path app. PMR is an established stress-reduction technique and serves as an active comparator matched in format, frequency, and duration. The control group completes two audio-guided PMR sessions per day and one brief reflection unit each evening. It is hypothesized that the reward intervention will (a) reduce anhedonia and psychological distress more effectively than PMR and (b) lead to specific improvements in reward processing.
Eligibility criteria
Inclusion Criteria: * German speaking * Smartphone available and willingness to participate in repeated training units and questions delivered via app * Clinically elevated anhedonia (SHAPS \>= 25) and elevated depression (DASS-21-Depression \>= 10), elevated anxiey (DASS-21-Anxiety \>= 6) or elevated stress (DASS-21-Stress \>= 10) Exclusion Criteria: * Psychotropic medication * Psychotherapy currently ongoing or planned during participation * Suicidality, lifetime diagnosis of bipolar disorders or psychotic episodes
Study design
Enrollment target: 60 participants
Allocation: randomized
Masking: single
Age groups: adult, older_adult
Timeline
Starts: 2025-06-18
Estimated completion: 2026-01
Last updated: 2026-01-09
Interventions
Behavioral: Training of reward processing/sensitivityBehavioral: Relaxation Training (PMR)Other: Psychoeducation
Primary outcomes
  • Change in anhedonia/hedonic capacity; measured with the Snaith-Hamilton Pleasure Scale (SHAPS) from baseline to post-intervention and baseline to 3-months follow-up (Baseline, 2 weeks (completion of intervention) and 3 months)
  • Change in depression, anxiety and stress; measured with the Depression-Anxiety-Stress-Scale (DASS-21) from baseline to completion and baseline to follow-up (Baseline, 2 weeks (completion of intervention) and 3 months)
Sponsor
Philipps University Marburg · other
Contacts & investigators
ContactMartin J Skopp, M.Sc. · contact · martin.skopp@uni-marburg.de · +4964212827106
All locations (1)
Philipps-University MarburgRecruiting
Marburg, Hesse, Germany
Ecological Momentary Intervention for Reward in Anhedonia · TrialPath