← Back to searchRecruitingRecruiting
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
NCT07177352 · Hoffmann-La Roche
In plain English
Click the button to translate this study into plain language — what it is, who qualifies, and what participation looks like.
Official title
Master Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies as Assessed by Biomarker Status and Cognition
About this study
This study is a pre-screening process used to assess participants' potential eligibility for Roche interventional Alzheimer's disease studies.
Eligibility criteria
Inclusion Criteria:
\- Report of objective or subjective memory concerns (by the participant and/or their informant) within the last year with or without a previous clinical diagnosis of MCI or dementia due to AD.
Exclusion Criteria:
* Dependency in basic activities of daily living (bADLs) due to cognitive impairment
* Visual or auditory impairment that would prevent them from performing the cognitive assessments (eyeglasses and hearing aids are permitted)
* Any self-reported evidence or known diagnosis of a neurological or neurodegenerative condition that may lead to cognitive impairment other than AD
* History of severe, clinically significant central nervous system trauma
* Any serious medical condition that precludes a participant's safe participation and completion of a clinical study
Study design
Enrollment target: 13000 participants
Allocation: na
Masking: none
Age groups: adult, older_adult
Timeline
Starts: 2025-07-02
Estimated completion: 2035-07-31
Last updated: 2026-04-06
Interventions
Other: No Intervention
Primary outcomes
- • Concentration of pTau217 in Blood on Day1 (Day 1)
- • Cognitive score in ISLT on Day 1 (Day 1)
Sponsor
Hoffmann-La Roche · industry
Contacts & investigators
ContactReference Study ID Number: WP45722 https://forpatients.roche.com/ · contact · global-roche-genentech-trials@gene.com · 888-662-6728 (U.S. and Canada)
InvestigatorClinical Trials · study_director, Hoffmann-La Roche
All locations (211)
University of Alabama at BirminghamRecruiting
Birmingham, Alabama, United States
Banner Alzheimer?s InstituteRecruiting
Phoenix, Arizona, United States
Banner Sun Health Research InstituteRecruiting
Sun City, Arizona, United States
Sun Valley Research Center, Inc.Recruiting
Imperial, California, United States
Inglewood ClinicalsRecruiting
Inglewood, California, United States
Irvine Center for Clinical ResearchRecruiting
Irvine, California, United States
Healthy Brain ClinicRecruiting
Long Beach, California, United States
Oakland ClinicalRecruiting
Oakland, California, United States
Riverside ClinicalRecruiting
Riverside, California, United States
Syrentis Clinical ResearchRecruiting
Santa Ana, California, United States
Cenexel California Neuroscience Research, LLCRecruiting
Sherman Oaks, California, United States
Yale UniversityRecruiting
New Haven, Connecticut, United States
JEM Research LLCRecruiting
Atlantis, Florida, United States
K2 Medical Research-Winter GardenRecruiting
Clermont, Florida, United States
K2 Medical Research - The VillagesRecruiting
Lady Lake, Florida, United States
K2 Medical Research, LLCRecruiting
Maitland, Florida, United States
Visionary Investigators Network- Neurology AventuraRecruiting
Miami, Florida, United States
Renstar Medical ResearchRecruiting
Ocala, Florida, United States
Charter Research - Winter Park/OrlandoRecruiting
Orlando, Florida, United States
Conquest Research - Lake NonaRecruiting
Orlando, Florida, United States
Alzheimer's Research and Treatment CenterRecruiting
Stuart, Florida, United States
Axiom Brain Health LLCRecruiting
Tampa, Florida, United States
Charter Research - Lady Lake/The VillagesRecruiting
The Villages, Florida, United States
Alzheimer?s Research and Treatment CenterRecruiting
Wellington, Florida, United States
Conquest Research, LLCRecruiting
Winter Park, Florida, United States
Grady Memorial HospitalRecruiting
Atlanta, Georgia, United States
Alzheimer's Research and Treatment Center - ColumbusRecruiting
Columbus, Georgia, United States
Accel Research Sites-NeuroStudiesRecruiting
Decatur, Georgia, United States
CenExel iResearch, LLCRecruiting
Decatur, Georgia, United States
Center for Advanced Research & EducationRecruiting
Gainesville, Georgia, United States
Hawaii Pacific NeuroscienceRecruiting
Honolulu, Hawaii, United States
RE:Cognition (Chicago)Recruiting
Chicago, Illinois, United States
Great Lakes Clinical Trials Chicago d/b/a Flourish Research AndersonvilleRecruiting
Chicago, Illinois, United States
Tandem Clinical Research, LLCRecruiting
Marrero, Louisiana, United States
Adams Clinical BostonRecruiting
Boston, Massachusetts, United States
Boston Center for MemoryRecruiting
Newton, Massachusetts, United States
Adams Clinical WatertownRecruiting
Watertown, Massachusetts, United States
Quest Research InstituteRecruiting
Farmington Hills, Michigan, United States
Washington University School of MedicineClinical Translational Research UnitRecruiting
St Louis, Missouri, United States
The Cognitive and Research Center of New JerseyRecruiting
Ridgewood, New Jersey, United States
The Cognitive and Research Center of New JerseyRecruiting
Springfield, New Jersey, United States
IMA Clinical Research - AlbuquerqueRecruiting
Albuquerque, New Mexico, United States
Basil ClinicalRecruiting
Laurelton, New York, United States
Weill Cornell Medical CollegeRecruiting
New York, New York, United States
Adams Clinical HarlemRecruiting
New York, New York, United States
AD-CARE, University of Rochester Medical CenterRecruiting
Rochester, New York, United States
Adams Clinical BronxRecruiting
The Bronx, New York, United States
Triad Clinical TrialsRecruiting
Greensboro, North Carolina, United States
Ohio State UniversityRecruiting
Columbus, Ohio, United States
Summit Research Network Inc.Recruiting
Portland, Oregon, United States
Flourish Research ? PhiladelphiaRecruiting
Plymouth Meeting, Pennsylvania, United States
Butler HospitalRecruiting
Providence, Rhode Island, United States
Ralph H. Johnson VA Medical CenterRecruiting
Charleston, South Carolina, United States
Palmetto Clinical TrialsRecruiting
Summerville, South Carolina, United States
Genesis Neuroscience ClinicRecruiting
Knoxville, Tennessee, United States
K2 Medical Research - NashvilleRecruiting
Nashville, Tennessee, United States
Gadolin Research, LLCRecruiting
Beaumont, Texas, United States
South Texas Research Institute - BrownsvilleRecruiting
Brownsville, Texas, United States
Kerwin Medical CenterRecruiting
Dallas, Texas, United States
Kerwin Research Center, LLCRecruiting
Dallas, Texas, United States
South Texas Research Institute - EdinburgRecruiting
Edinburg, Texas, United States
Re:Cognition Health - Fort WorthRecruiting
Fort Worth, Texas, United States
Re:Cognition Health - HoustonRecruiting
Houston, Texas, United States
Mt.Olympus Medical ResearchRecruiting
Katy, Texas, United States
El Faro Health and TherapeuticsRecruiting
Rio Grande City, Texas, United States
Sana Research, LLCRecruiting
Arlington, Virginia, United States
Re:Cognition HealthRecruiting
Fairfax, Virginia, United States
National Clinical Research Inc.-RichmondRecruiting
Richmond, Virginia, United States
INECO Neurociencias OronoRecruiting
Rosario, Santa Fe Province, Argentina
Hospital Italiano de Buenos AiresRecruiting
Buenos Aires, Argentina
CIERRecruiting
C. A. B. A., Argentina
Fundacion ScherbovskyRecruiting
Mendoza, Argentina
Sanatorio del Sur S.A.Recruiting
San Miguel de Tucumán, Argentina
Royal Prince Alfred HospitalRecruiting
Camperdown, New South Wales, Australia
St Vincent's Hospital SydneyRecruiting
Darlinghurst, New South Wales, Australia
Southern NeurologyRecruiting
Kogarah, New South Wales, Australia
KaRa Institute of Neurological DiseasesRecruiting
Macquarie Park, New South Wales, Australia
Flinders Medical CentreRecruiting
Bedford Park, South Australia, Australia
Queen Elizabeth HospitalRecruiting
Woodville, South Australia, Australia
Box Hill HospitalRecruiting
Box Hill, Victoria, Australia
Heidelberg Repatriation HospitalRecruiting
Heidelberg, Victoria, Australia
Alfred HealthRecruiting
Melbourne, Victoria, Australia
Royal Melbourne HospitalRecruiting
Parkville, Victoria, Australia
Instituto de Neurologia de CuritibaRecruiting
Curitiba, Paraná, Brazil
Clinica Clinilive ltdaRecruiting
Maringá, Paraná, Brazil
Hospital Moinhos de VentoRecruiting
Porto Alegre, Rio Grande do Sul, Brazil
Hospital das Clinicas - UFRGSRecruiting
Porto Alegre, Rio Grande do Sul, Brazil
Instituto do Cerebro do Rio Grande do SulRecruiting
Porto Alegre, Rio Grande do Sul, Brazil
Clinica NeurologicaRecruiting
Joinville, Santa Catarina, Brazil
Centro Multidisciplinar de Estudos Clínicos - CEMEC*X*Recruiting
São Bernardo do Campo, São Paulo, Brazil
Centro de Pesquisas Clinicas - CPCLINRecruiting
São Paulo, São Paulo, Brazil
Okanagan Clinical TrialsRecruiting
Kelowna, British Columbia, Canada
Richmond Clinical TrialsRecruiting
Richmond, British Columbia, Canada
Centricity ResearchRecruiting
Halifax, Nova Scotia, Canada
Parkwood Institute, Mental Health Care BuildingRecruiting
London, Ontario, Canada
Bruyère Health Research InstituteRecruiting
Ottawa, Ontario, Canada
The Ottawa Memory ClinicRecruiting
Ottawa, Ontario, Canada
Kawartha Regional Memory ClinicRecruiting
Peterborough, Ontario, Canada
Toronto Memory ProgramRecruiting
Toronto, Ontario, Canada
Centricity East YorkRecruiting
Toronto, Ontario, Canada
Sunnybrook Health Sciences CentreRecruiting
Toronto, Ontario, Canada
St. Michael's HospitalRecruiting
Toronto, Ontario, Canada
Toronto Western HospitalRecruiting
Toronto, Ontario, Canada
Baycrest Health SciencesRecruiting
Toronto, Ontario, Canada
Clinique Memoire de MontrealRecruiting
Montreal, Quebec, Canada
Genge Partners Inc.Recruiting
Montreal, Quebec, Canada
Alpha Recherche CliniqueRecruiting
Québec, Canada
Peking University First HospitalRecruiting
Beijing, Beijing Municipality, China
The Affiliated Hospital of Xuzhou Medical UniversityRecruiting
Xuzhou, Jiangsu, China
Beijing Friendship Hospital Affiliated of Capital University of Medical ScienceRecruiting
Beijing, China
The First Hospital of Jilin UniversityRecruiting
Changchun, China
West China Hospital - Sichuan UniversityRecruiting
Chengdu, China
The First Affiliated Hospital, Chongqing Medical UniversityRecruiting
Chongqing, China
The second Affiliated Hospital of Guangzhou Medical UniversityRecruiting
Guangzhou, China
Guangdong General HospitalRecruiting
Guangzhou, China
The First Affiliated Hospital of Anhui Medical UniversityRecruiting
Hefei, China
Zhongda Hospital Affiliated to Southeast UniversityRecruiting
Nanjing, China
Nanjing Brain HospitalRecruiting
Nanjing, China
Nanjing First HospitalRecruiting
Nanjing, China
Huashan Hospital, Fudan UniversityRecruiting
Shanghai, China
Shanghai First People's HospitalRecruiting
Shanghai, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineRecruiting
Shanghai, China
The Second Affiliated Hospital of Soochow UniversityRecruiting
Suzhou, China
Aalborg UniversitetshospitalRecruiting
Aalborg, Denmark
Aarhus Universitetshospital SkejbyRecruiting
Aarhus N, Denmark
Rigshospitalet, HukommelsesklinikkenRecruiting
København Ø, Denmark
A. O. U. Federico IIRecruiting
Naples, Campania, Italy
Policlinico Universitario Agostino GemelliRecruiting
Rome, Lazio, Italy
Fondazione Santa Lucia IRCCSRecruiting
Rome, Lazio, Italy
Umberto I Policlinico di Roma-Università di Roma La SapienzaRecruiting
Rome, Lazio, Italy
Ospedale Isola Tiberina - Gemelli IsolaRecruiting
Rome, Lazio, Italy
Irccs A.O.U.San Martino IstRecruiting
Genoa, Liguria, Italy
Asst Degli Spedali Civili Di BresciaRecruiting
Brescia, Lombardy, Italy
IRCCS Ospedale San RaffaeleRecruiting
Milan, Lombardy, Italy
AOU Policlinico GiacconeRecruiting
Palermo, Sicily, Italy
AO di Perugia - Ospedale S. Maria della MisericordiaRecruiting
Perugia, Umbria, Italy
Brain Attack Center Ota Memorial HospitalRecruiting
Hiroshima, Japan
National Hospital Organization Hiroshima-Nishi Medical CenterRecruiting
Hiroshima, Japan
Kobe University HospitalRecruiting
Hyōgo, Japan
Kagawa University HospitalRecruiting
Kagawa, Japan
Kochi Medical School HospitalRecruiting
Kochi, Japan
Kyoto University HospitalRecruiting
Kyoto, Japan
National Hospital Organization Utano National HospitalRecruiting
Kyoto, Japan
Mishuku HospitalRecruiting
Meguro-Ku, Japan
Mie University HospitalRecruiting
Mie, Japan
Okayama City HospitalRecruiting
Okayama, Japan
Rijikai Medical Corporation Katayama Medical ClinicRecruiting
Okayama, Japan
Kotobuki Social Medical Corporation Tominaga ClinicRecruiting
Osaka, Japan
Memory Clinic OchanomizuRecruiting
Tokyo, Japan
The University of Tokyo HospitalRecruiting
Tokyo, Japan
Keio University HospitalRecruiting
Tokyo, Japan
Higashi-Shinjuku ClinicRecruiting
Tokyo, Japan
Tokyo Metropolitan Geriatric HospitalRecruiting
Tokyo, Japan
National Center of Neurology and PsychiatryRecruiting
Tokyo, Japan
Federation of National Public Service Personnel Mutual Aid Associations Tachikawa HospitalRecruiting
Tokyo, Japan
P-One ClinicRecruiting
Tokyo, Japan
Yamagata Tokusyukai HospitalRecruiting
Yamagata, Japan
ProNeuro Centrum MedyczneRecruiting
?ory, Poland
Uniwersytet Medyczny w LodziRecruiting
?ód?, Poland
Syberka-ClinHouse Sp. z o.o.Recruiting
B?dzin, Poland
Podlaskie Centrum PsychogeriatriiRecruiting
Bia?ystok, Poland
Centrum Medyczne Neuromed Sp. z.o.o.Recruiting
Bydgoszcz, Poland
Centrum Badan Klinicznych PI-House sp. z o.o.Recruiting
Gda?sk, Poland
Uniwersyteckie Centrum Kliniczne;Klinika Neurologii Doros?ychRecruiting
Gdansk, Poland
Neuro-Care Gabriela KlodowskaRecruiting
Katowice, Poland
Szpital Uniwersytecki w KrakowieRecruiting
Krakow, Poland
Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii KRecruiting
Krakow, Poland
Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.Recruiting
Lublin, Poland
Clinical Research Center Sp. z o.o. MEDIC-R Spó?ka KomandytowaRecruiting
Późna, Poland
Nmedis sp. z o.o.Recruiting
Rzeszów, Poland
Centrum Medyczne MedykRecruiting
Rzeszów, Poland
Senior Sp. Z O.O. Poradnia PsychogeriatrycznaRecruiting
Sopot, Poland
O?rodek Badawczo-Naukowo-Dydaktyczny Chorób Ot?piennych w ?cinawieRecruiting
Ścinawa, Poland
Centrum Medyczne NeuroProtectRecruiting
Warsaw, Poland
ETG Neuroscience Sp. z o.o.Recruiting
Warsaw, Poland
Centrum Leczenia Zaburzen PamieciRecruiting
Warsaw, Poland
NZOZ WCARecruiting
Wroc?aw, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Stanislawa SzyszkoSUM w KatowicachRecruiting
Zabrze, Poland
University of Puerto Rico - Medical Science CampusRecruiting
San Juan, Puerto Rico
Chonnam National University HospitalRecruiting
Gwangju, South Korea
St. Vincent's HospitalRecruiting
Gyeonggi-do, South Korea
Inha University HospitalRecruiting
Incheon, South Korea
Gachon University Gil Medical CenterRecruiting
Namdong-gu, South Korea
Seoul National University Bundang HospitalRecruiting
Seongnam-si, South Korea
Hanyang University Seoul HospitalRecruiting
Seoul, South Korea
Samsung Medical CenterRecruiting
Seoul, South Korea
Ewha Womans University Hospital (Seoul)Recruiting
Seoul, South Korea
Korea University Guro HospitalRecruiting
Seoul, South Korea
Asan Medical CenterRecruiting
Seoul, South Korea
Ajou University Medical CenterRecruiting
Suwon, South Korea
Hospital de Dénia;Servicio de NeurologíaRecruiting
Denia, Alicante, Spain
Fundació Hospitalàries Martorell;NeurologyRecruiting
Martorell, Barcelona, Spain
Hospital Mutua De TerrasaRecruiting
Terrassa, Barcelona, Spain
Hospital Quiron de MadridRecruiting
Pozuelo de Alarcón, Madrid, Spain
Fundación ACERecruiting
Barcelona, Spain
Hospital Vall d'HebronRecruiting
Barcelona, Spain
Hospital de la Santa Creu i Sant PauRecruiting
Barcelona, Spain
Hospital Universitario Reina SofiaRecruiting
Córdoba, Spain
Policlínica GuipuzkoaRecruiting
Donosti-San Sebastián, Spain
Hospital San CecilioRecruiting
Granada, Spain
Hospital Universitario de la PrincesaRecruiting
Madrid, Spain
Hospital Universitario 12 de OctubreRecruiting
Madrid, Spain
Hospital Virgen del RocíoRecruiting
Seville, Spain
Hospital Universitario Dr. PesetRecruiting
Valencia, Spain
Hospital Universitario la FeRecruiting
Valencia, Spain
Kaohsiung Medical University HospitalRecruiting
Kaohsiung City, Taiwan
Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - NeurologyRecruiting
Kwei Shen, Taiwan
Taipei Medical University - Shuang Ho Hospital - NeurologyRecruiting
New Taipei City, Taiwan
China Medical University HospitalRecruiting
North Dist., Taiwan
Taichung Veterans General HospitalRecruiting
Taichung, Taiwan
National Taiwan University HospitalRecruiting
Taipei, Taiwan